[Results of a pilot study of the structure and evaluation of the therapy for chronic sleep disorders in comorbid patients with chronic cerebral ischemia].

Objective: To evaluate the effect of the drug Cortexin on the clinical course and treatment of comorbid insomnia.

Material And Methods: The study included 50 patients, average age 50.4±2.

[The result of prospective randomized study CITADEL - the efficacy and safety of drug cytoflavin in postcovid rehabilitation].

Objective: To investigate the structure of postcovid syndrome, age and gender characteristics of its course, and to assess the effect of Cytoflavin on the clinical course of neurological disorders in patients who have undergone COVID-19.

Material And Methods: The study included 100 patients, the average age was 40.4±11.

[Herpesvirus infection in patients with chronic glomerulonephritis].

Virological examinations of blood, urine and saliva in 75 patients with chronic glomerulonephritis (CG) revealed, in 95% of them, herpes-virus infections caused by herpes simplex virus, type 1 (34.4%), herpes simplex virus, type 2 (2.6%) and cytomegalovirus (12%) or mixed infections (46%).

[Use of computerized psychodiagnostic methods for occupational orientation of adolescents with scoliosis].

The paper deals with the characteristic features and problems of professional self-determination in adolescents with scoliosis, studied by using computer and project psychological methods. A complex of methods revealed the following psychological characteristics in the adolescents of the study group: emotional-and-motivational direction, adequacy of job choice, mental tension, self-assessment, possible pain symptoms in neurotic disorders.

[Viral antigens in kidney biopsies of children with glomerulonephritis].

A relationship between clinical forms of glomerulonephritis and incidence of viral antigens in renal tissue was revealed: Hepatitis B virus antigens (HBsAg) are more frequently detected in the glomeruli in the patients with nephrotic glomerulonephritis, Herpes simplex antigens are detected in the glomeruli in mixed glomerulonephritis, and cytomegaloviral and Herpes simplex antigens are detected in the epithelium of the proximal canaliculi in patients with hematuric glomerulonephritis. No correlations between the persistence of Herpes simplex type 1, cytomegalovirus, and HBsAg in the renal tissue were detected. HBsAg is detected in the renal tissue mainly in the children without free HBsAg in the blood serum.

[The use of immunostimulants for enhancing the immunogenicity of a herpes vaccine].

National immunostimulators and interferon inducers (poludan, ridostin, larifan, myelopide, vegetan) in combination with a commercial herpes vaccine (HV) were used for experimental immunization of mice. A 3-fold or greater rise of specific antibody titres was observed after a single immunization of intact BALB/c mice. In experiments in chronically infected animals a single inoculation of HV resulted in a 3-fold rise of specific antibody titres at 6 days postimmunization but not in later periods (20, 30 days).

[The diagnosis of herpesvirus infection in patients with organ allografts].

The diagnostic value of three methods for detection of herpes virus infection caused by herpes simplex virus and cytomegaloviruses was investigated in patients with allotransplanted organs. The method of molecular hybridization was demonstrated to be more sensitive in diagnosing herpes virus infection than virological and cytological methods. Herpes virus infection can be effectively diagnosed by a complex of methods including the detection of cytomegalic cells in the urine and saliva.

[The effect of herpesvirus infections on the results of a kidney allograft].

It was shown to be necessary to control the level of antibody to cytomegalovirus in order to improve the selection of donor-recipient pairs. High antibody titres to cytomegalovirus constitute one of contraindications against allotransplantation.