Penehyclidine Hydrochloride Improves Rhabdomyolysis-Mediated Acute Kidney Injury by Inhibiting Ferroptosis through the HIF-1α/MT1G Axis.

Background: Penehyclidine hydrochloride (PHC) has been shown to be effective in the treatment of rhabdomyolysis (RM)-induced acute kidney injury (AKI). Our research sought to investigate the pharmacological effects and mechanisms of PHC on RM-induced AKI.

Methods: RM-induced AKI models were established by FeG treatment and glycerol injection.

Effect of Different Iron Sources on Growth of Zeolitic Imidazolate Frameworks-8: For Efficient Oxygen Reduction Electrocatalysts.

Transition metal and nitrogen co-doped carbon-based catalysts (TM-N-C) have become the most promising catalysts for Pt/C due to their wide range of sources, low cost, high catalytic activity, excellent stability and strong resistance to poisoning, especially Fe-N-C metal-organic frameworks (MOFs), which are some of the most promising precursors for the preparation of Fe-N-C catalysts due to their inherent properties, such as their highly ordered three-dimensional framework structure, controlled porosity, and tuneable chemistry. Based on these, in this paper, different iron sources were added to synthesis a sort of zeolitic imidazole frameworks (ZIF-8). Then the imidazole salt in ZIF-8 was rearranged into high N-doped carbon by high-temperature pyrolysis to prepare the Fe-N-C catalyst.

[Analysis of Phenotype and Genotype of A Family with Hereditary Coagulation Factor Ⅴ Deficiency Caused by A Compound Heterozygous Mutation].

Objective: To analyze the molecular pathogenesis by analysis of phenotype and gene mutation in families with hereditary coagulation factor V (FⅤ) defect caused by complex heterozygous mutation.

Methods: Plasma pro-thrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), FⅤ procoagulant activity (FⅤ∶C), FⅤ antigen (FⅤ∶Ag), and other related coagulation indexes were detected in the proband and his family members (3 generations 10 people). Using DNA direct sequencing to analyze all exons, flanks, 5' and 3' untranslated regions of F5 genes and the corresponding mutation site regions of family members, the mutation site was confirmed by reverse sequencing．The conservation of mutant amino acids was analyzed by ClustalX-2.

[Development of national neglect norm for urban primary school students of China].

Objective: To develop the national neglect norms for urban primary school students in China.

Methods: According to multi-stage stratified cluster sampling principle, 24 cities of 13 provinces (municipalities) in China were selected during December 1 to 31, 2008. A total of 1491 students in grade 1 - 3 and 2236 students in grade 4 - 6 were selected.

[The effect of AQP4 gene on the activation of retinal glial cells in chronic high intraocular pressure mice].

Objectives: To investigate whether aquaporin 4 (AQP4) gene can affect the activation of glial cells and cause the injury of retina of chronic high intraocular pressure mice models, and to discuss its possible mechanism.

Methods: Experimental study. The chronic high intraocular pressure models were established by burning the scleral venous of the right eye, which as the experiment group, and the left eye without any treatment as the control group.

[Development of the National Norms of Negligence on children aged 0 to 35 months in rural areas of China].

Objective: To develop the National Norms of Negligence (NNN) for rural children aged 0 to 35 months.

Methods: According to multi-stage stratified cluster sampling principle, 10 provinces or municipalities (Jilin, Shanxi, Shanxi, Beijing, Anhui, Jiangsu, Hunan, Hubei, Yunnan, Chongqing) in China were selected. A national research group was formed collaboratively.

[The status of child neglect for children aged 3 - 17 years in China].

Objective: To explore the status of child neglect among urban areas children and adolescents aged 3 - 17 years in China.

Methods: Using multi-stage stratified cluster sampling method, 8001 children and adolescents were recruited from 30 cities of 14 provinces in December 2008. The investigation was carried based on The 3 - 6 years old children Neglect Norms of city in China and The 6 - 17 years old children Neglect Norms of city in China.

[Development of national neglect norms for children aged 3 to 6 years in rural areas of China].

Objective: To develop the national neglect norms for rural children aged 3 to 6 years, which are suitable for Chinese situations.

Methods: According to the multi-stage stratified cluster sampling principle, 84 towns of 10 provinces or municipalities were selected in China. Children aged 3 to 6 years were surveyed in November 2010, the sample of analysis were 3240 (of whom males were 49.

The personal experiences of HIV/AIDS patients in rural areas of western China.

Because of unique economic, cultural, and social factors, the personal experiences of HIV/AIDS patients in the rural areas of western China are not well understood. The aim of this study was to explore HIV/AIDS patients' thoughts and personal experiences in the environment and conditions of rural western China. Sixteen HIV/AIDS patients from remote western areas of China were interviewed by using an established qualitative method, during April to June 2008.