Publications by authors named "Sha-Sha Zuo"
Moutai Jiuqu is a famous aromatic raw material of Maotai flavor liquor in China. It is brewed at high temperature and contains many kinds of bacteria, molds, and yeasts. There are many useful glycoside hydrolases in these microfloras, from which efficient glycoside hydrolases can be screened for biotransformation of natural saponins.
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- * After treatment, measurements of serum blood urea nitrogen (BUN), creatinine (Cre), and urinary protein levels indicated significant renal injury in the model group, along with increased inflammatory factors linked to specific pathways (NLRP3 and TLR4/NF-κB).
- * Administration of anemoside B4 resulted in decreased levels of BUN, Cre, and urinary protein in certain dosage groups, demonstrating its potential to alleviate renal tubular injury and reduce inflammation.
This paper was aimed to observe the effect of anemoside B4(hereinafter referred to as B4) on cisplatin-induced acute kidney injury in mice, and to investigate its possible mechanism in renal protection from inflammation and apoptosis aspects. Mice were divided into normal group, model group, dexamethasone positive group and B4 high, middle and low dose groups(5, 2.5, and 1.
View Article and Find Full Text PDF[Study on acute kidney injury model induced by renal ischemia-reperfusion in rats].
Zhongguo Zhong Yao Za Zhi
March 2019
Article Synopsis
- This study focused on evaluating acute kidney injury (AKI) in male SD rats caused by renal arteriovenous ligation to enhance drug research methodologies.
- The procedure involved 40 minutes of ligation followed by 24 hours of reperfusion, revealing significant increases in serum creatinine (Crea) and blood urea nitrogen (BUN) levels, particularly with mixed renal artery and vein ligation.
- Additionally, the study found considerable pathological changes in kidney tissues, alongside notable increases in mRNA expression of inflammatory markers, indicating a pronounced response linked to the severity of kidney injury.