Asymmetric Synthesis of S(IV)-Stereogenic Sulfinimidate Esters by Sulfinamide Activation.

Catalyst-controlled approaches for the synthesis of S-stereogenic compounds have propelled significant advancements in asymmetric synthetic chemistry. In contrast, control over S-heteroatom (e.g.

Prognostic relevance of immunoglobulin heavy chain rearrangement and immunoglobulin kappa light chain rearrangement in patients with diffuse large B cell lymphoma.

Purposes: Evidence has demonstrated that monitoring of the variable, diversity, and joining gene segments (VDJ) rearrangement of immunoglobulin (Ig) gene in the circulating tumor DNA (ctDNA) is highly valuable in predicting the prognosis of patients with diffuse large B cell lymphoma (DLBCL). In this study, we investigated the role of both Ig heavy chain (IGH) and Ig kappa light chain (IGK) gene rearrangements detected in ctDNA samples in predicting DLBCL progression.

Methods: Next-generation sequencing (NGS) was used to identify the dominant V(D)J clonotypic rearrangement in tissue samples of 33 DLBCL patients.

Effectiveness of Digital Diabetes Management Technology on Blood Glucose in Patients With Type 2 Diabetes at Home: Systematic Review and Meta-Analysis.

Background: Patients with type 2 diabetes mellitus (T2DM) face elevated morbidity, mortality, and care costs. Digital self-monitoring of blood glucose (SMBG) can automatically upload data to apps, share the data with health care providers, reduce errors, and aid long-term diabetes management.

Objective: This study aimed to assess the effectiveness of digital diabetes management techniques based on digital SMBG on blood glucose in patients with T2DM at home.

The effect of cannabinoid type Ⅱ receptor on the excitability of substantia nigra dopaminergic neurons.

The biological effects of cannabinoids are mainly mediated by two members of the G-protein-coupled-receptor family: cannabinoid type 1 receptor (CB1R) and cannabinoid type 2 receptor (CB2R). Unlike CB1R, CB2R is considered a "peripheral" cannabinoid receptor. However, recent studies have found that CB2R is widely expressed in the central nervous system and is involved in dopamine related behavioral regulation, including dietary behavior, weight regulation, anxiety, and schizophrenia like behavior.

Metal-Free Alkane Functionalization by Organocatalytic and Photoinduced Methods.

Transforming alkane C-H bonds into carbon-carbon and carbon-heteroatom bonds represents a paramount objective in synthetic chemistry with significant implications for sustainable production. Although transition-metal catalysts such as Pd, Rh etc have dominated this field, recent breakthroughs in metal-free approaches leveraging small-molecule catalysts or photogenerated intermediates have emerged as efficient and sustainable alternatives. These approaches facilitate precise C-H bond activation and selective formation of C-X (e.

Experimental evidence for viral impact on microbial community, nitrification, and denitrification in an agriculture soil.

Viruses are ubiquitous, and their potential impacts on biogeochemical cycles in soil have largely been inferred from correlation evidence and virome studies. Manure has been demonstrated to affect nitrogen cycle by altering soil nutrients and microbial communities. However, the direct impacts of viruses derived from manure on microbial community, nitrification, and denitrification remained exclusive.

LPSGM: A Unified Flexible Large PSG Model for Sleep Staging and Mental Disorder Diagnosis.

We present the Large PSG Model (LPSGM), a unified and flexible framework for sleep staging and disease diagnosis using polysomnography (PSG) data. LPSGM is designed to address the challenges of cross-center generalization in sleep staging and to enable fine-tuning for downstream disease diagnosis tasks. LPSGM introduces a unified training framework for heterogeneous datasets and allows flexible channel input adjustments during inference.

Sustained yet non-curative response to lenalidomide in relapsed angioimmunoblastic T-cell lymphoma with acquired chidamide resistance: a case report with 10-year follow-up, genetic insights and literature review.

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphoma (PTCL) characterized by its T-follicular helper (TFH) phenotype. Relapsed and refractory disease is common in AITL and often associated with a poor prognosis. The presence of epigenetic abnormalities, immune dysregulation, hyperinflammation and active angiogenesis in AITL offers potential targets for histone deacetylase (HDAC) inhibitors and immunomodulatory drugs (IMiDs).

Endocannabinoid interference blocks post-global cerebral ischemia depression through prefrontal cortico-amygdala projections.

Up to 45% of patients surviving from transient global cerebral ischemia (GCI) after cardiac arrest develop post-global cerebral ischemia depression (PGCID), but how to treat PGCID is clinically unknown. Here we find that cannabinoid type-1 receptor (CBR) antagonists, CBR knockout and endocannabinoid (eCB) synthesis inhibition block acute stress-induced PGCID. Application of acute stress to GCI mice increases CBR activity from ventromedial prefrontal cortical (vmPFC) terminals synapsing with the basolateral amygdala (BLA) neurons, indicating the involvement of increased vmPFC-BLA synaptic eCB signaling in PGCID induction.

Challenges and strategies toward oncolytic virotherapy for leptomeningeal metastasis.

Meningeal metastasis (LM) is commonly seen in the advanced stages of cancer patients, often leading to a rapid decline in survival time and quality of life. Currently, there is still a lack of standardized treatments. Oncolytic viruses (OVs) are a class of emerging cancer therapeutics with the advantages of selectively replicating in cancer cells, delivering various eukaryotic transgenes, inducing immunogenic cell death, and promoting anti-tumor immunity.

High-Performance Supercapacitive Pressure Sensors via Height-Grading Micro-Domes of Ionic Conductive Elastomer.

Soft capacitive sensors present numerous appealing characteristics, including simple structure, low power consumption, and fast response. However, they often suffer from low sensitivity and a limited linear sensing range. Herein, a concept is presented to enhance the sensitivity and linearity of supercapacitive pressure sensors by functionally grading the heights of macrodomes constructed from a highly elastic and ionic conductive elastomer made of poly(vinyl alcohol) and phosphoric acid (PVA/HPO).

Interventions to improve illness-related communication between cancer patients and their minor children: A systematic review.

Background: Parental cancer conditions significantly impact the physical, social, and emotional well-being of minor children. Effective illness-related communication is crucial for both parents and their children to mitigate these effects.

Objective: To systematically summarize the characteristics and effectiveness of interventions aimed at improving illness-related communication between parents with cancer and their minor children.

Cannabinoids and monoaminergic system: implications for learning and memory.

Cannabinoids and the endocannabinoid system (ECS) have been intensively studied for their neuroregulatory roles in the central nervous system (CNS), especially in regulating learning and memory. However, many experimental and clinical studies obtained conflicting results indicating a complex network of interaction underlying the regulation of learning and memory by different cannabinoids and the ECS. The ECS influences neuronal synaptic communications, and therefore may exert different regulation via their different impact on other neurotransmitters.

A case report of primary central nervous system lymphoma with immune deficiency/disorder setting diagnosed by cerebrospinal fluid cytology.

Cerebrospinal fluid (CSF) cytology of primary central nervous system lymphoma arising in the immune deficiency/dysregulation setting (IDD-PCNSL) has not been described. This study presented a case of IDD-PCNSL-DLBCL, a GCB phenotype who was successfully diagnosed by CSF cytology in conjunction with ICC, ISH, FCM and clinical information.

CareSleepNet: A Hybrid Deep Learning Network for Automatic Sleep Staging.

Sleep staging is essential for sleep assessment and plays an important role in disease diagnosis, which refers to the classification of sleep epochs into different sleep stages. Polysomnography (PSG), consisting of many different physiological signals, e.g.

TET2 regulates extranodal NK/T cell lymphoma progression through regulation of DNA methylation.

The biological role of Ten-11 translocation 2 (TET2) and the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in the development of extra-nodal natural killer/T-cell lymphoma (ENKTL) remains unclear. The level of 5mC and 5hmC was detected in 112 cases of ENKTL tissue specimens by immunohistochemical (IHC) staining. Subsequently, TET2 knockdown and the overexpression cell models were constructed in ENKTL cell lines.