Publications by authors named "Sha Zhao"

Catalyst-controlled approaches for the synthesis of S-stereogenic compounds have propelled significant advancements in asymmetric synthetic chemistry. In contrast, control over S-heteroatom (e.g.

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Purposes: Evidence has demonstrated that monitoring of the variable, diversity, and joining gene segments (VDJ) rearrangement of immunoglobulin (Ig) gene in the circulating tumor DNA (ctDNA) is highly valuable in predicting the prognosis of patients with diffuse large B cell lymphoma (DLBCL). In this study, we investigated the role of both Ig heavy chain (IGH) and Ig kappa light chain (IGK) gene rearrangements detected in ctDNA samples in predicting DLBCL progression.

Methods: Next-generation sequencing (NGS) was used to identify the dominant V(D)J clonotypic rearrangement in tissue samples of 33 DLBCL patients.

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Background: Patients with type 2 diabetes mellitus (T2DM) face elevated morbidity, mortality, and care costs. Digital self-monitoring of blood glucose (SMBG) can automatically upload data to apps, share the data with health care providers, reduce errors, and aid long-term diabetes management.

Objective: This study aimed to assess the effectiveness of digital diabetes management techniques based on digital SMBG on blood glucose in patients with T2DM at home.

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The biological effects of cannabinoids are mainly mediated by two members of the G-protein-coupled-receptor family: cannabinoid type 1 receptor (CB1R) and cannabinoid type 2 receptor (CB2R). Unlike CB1R, CB2R is considered a "peripheral" cannabinoid receptor. However, recent studies have found that CB2R is widely expressed in the central nervous system and is involved in dopamine related behavioral regulation, including dietary behavior, weight regulation, anxiety, and schizophrenia like behavior.

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Transforming alkane C-H bonds into carbon-carbon and carbon-heteroatom bonds represents a paramount objective in synthetic chemistry with significant implications for sustainable production. Although transition-metal catalysts such as Pd, Rh etc have dominated this field, recent breakthroughs in metal-free approaches leveraging small-molecule catalysts or photogenerated intermediates have emerged as efficient and sustainable alternatives. These approaches facilitate precise C-H bond activation and selective formation of C-X (e.

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Viruses are ubiquitous, and their potential impacts on biogeochemical cycles in soil have largely been inferred from correlation evidence and virome studies. Manure has been demonstrated to affect nitrogen cycle by altering soil nutrients and microbial communities. However, the direct impacts of viruses derived from manure on microbial community, nitrification, and denitrification remained exclusive.

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We present the Large PSG Model (LPSGM), a unified and flexible framework for sleep staging and disease diagnosis using polysomnography (PSG) data. LPSGM is designed to address the challenges of cross-center generalization in sleep staging and to enable fine-tuning for downstream disease diagnosis tasks. LPSGM introduces a unified training framework for heterogeneous datasets and allows flexible channel input adjustments during inference.

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Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphoma (PTCL) characterized by its T-follicular helper (TFH) phenotype. Relapsed and refractory disease is common in AITL and often associated with a poor prognosis. The presence of epigenetic abnormalities, immune dysregulation, hyperinflammation and active angiogenesis in AITL offers potential targets for histone deacetylase (HDAC) inhibitors and immunomodulatory drugs (IMiDs).

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Up to 45% of patients surviving from transient global cerebral ischemia (GCI) after cardiac arrest develop post-global cerebral ischemia depression (PGCID), but how to treat PGCID is clinically unknown. Here we find that cannabinoid type-1 receptor (CBR) antagonists, CBR knockout and endocannabinoid (eCB) synthesis inhibition block acute stress-induced PGCID. Application of acute stress to GCI mice increases CBR activity from ventromedial prefrontal cortical (vmPFC) terminals synapsing with the basolateral amygdala (BLA) neurons, indicating the involvement of increased vmPFC-BLA synaptic eCB signaling in PGCID induction.

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Article Synopsis
  • Current percutaneous transthoracic needle biopsy (PTNB) systems face challenges, prompting the development of a new registration-free navigation system aimed at improving accuracy and efficiency in CT-guided procedures.
  • A study with 98 participants showed this new system achieved an impressive primary biopsy success rate of 98.98% with significantly fewer CT scans and a short procedure time of about 18 minutes.
  • While the system is deemed effective and safe, it did record few adverse events, primarily hemorrhage and pneumothorax, highlighting the importance of monitoring during clinical use.*
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  • The study assessed the effectiveness and safety of PEGylated-recombinant human growth hormone (PEG-rhGH) in children born small for gestational age (SGA).
  • Conducted in China, 96 SGA children were randomized to receive either a low dose (0.1 mg/kg/week) or high dose (0.2 mg/kg/week) of PEG-rhGH over 52 weeks.
  • Results showed significant improvements in height and growth velocity for those on the high dose compared to the low dose, with both treatments being well tolerated.
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Meningeal metastasis (LM) is commonly seen in the advanced stages of cancer patients, often leading to a rapid decline in survival time and quality of life. Currently, there is still a lack of standardized treatments. Oncolytic viruses (OVs) are a class of emerging cancer therapeutics with the advantages of selectively replicating in cancer cells, delivering various eukaryotic transgenes, inducing immunogenic cell death, and promoting anti-tumor immunity.

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Soft capacitive sensors present numerous appealing characteristics, including simple structure, low power consumption, and fast response. However, they often suffer from low sensitivity and a limited linear sensing range. Herein, a concept is presented to enhance the sensitivity and linearity of supercapacitive pressure sensors by functionally grading the heights of macrodomes constructed from a highly elastic and ionic conductive elastomer made of poly(vinyl alcohol) and phosphoric acid (PVA/HPO).

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  • * Initial diagnosis suggested infectious mononucleosis, but further biopsies confirmed systemic EBV DLBCL; the patient underwent successful treatment with R-CHOP chemotherapy, resulting in complete remission.
  • * Despite remission, the patient developed hemophagocytic lymphohistiocytosis (HLH) after the fifth treatment cycle and ultimately received allogeneic stem cell transplantation, but died 14 months later, highlighting the
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  • Vegetation influences air quality by reducing particulate matter (PM) and enhancing air purification through photosynthesis, but PM can also harm plants directly and indirectly by changing weather.
  • A study on warm-temperate forests in China from 2004 to 2022 found that the start of the growing season (SOS) advanced by 0.15 days per year, with PM positively correlated to SOS, especially in areas with dense road networks.
  • The analysis revealed that the relationship between PM and SOS was affected by relative humidity, and incorporating PM into a phenology model improved predictions of SOS, highlighting the complex interactions among environmental factors.
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Background: Parental cancer conditions significantly impact the physical, social, and emotional well-being of minor children. Effective illness-related communication is crucial for both parents and their children to mitigate these effects.

Objective: To systematically summarize the characteristics and effectiveness of interventions aimed at improving illness-related communication between parents with cancer and their minor children.

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  • Diagnosing patients who are not fully conscious is hard and can be incorrect, but using EEG, which records brain activity, helps a lot.
  • The new system called DOCTer uses EEG signals and patient information to tell the difference between two states: minimally conscious and unresponsive wakefulness.
  • With a big dataset of EEG recordings, DOCTer has shown to be really effective in finding the right diagnosis, which can help doctors create better treatment plans for patients.
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Cannabinoids and the endocannabinoid system (ECS) have been intensively studied for their neuroregulatory roles in the central nervous system (CNS), especially in regulating learning and memory. However, many experimental and clinical studies obtained conflicting results indicating a complex network of interaction underlying the regulation of learning and memory by different cannabinoids and the ECS. The ECS influences neuronal synaptic communications, and therefore may exert different regulation via their different impact on other neurotransmitters.

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Cerebrospinal fluid (CSF) cytology of primary central nervous system lymphoma arising in the immune deficiency/dysregulation setting (IDD-PCNSL) has not been described. This study presented a case of IDD-PCNSL-DLBCL, a GCB phenotype who was successfully diagnosed by CSF cytology in conjunction with ICC, ISH, FCM and clinical information.

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Sleep staging is essential for sleep assessment and plays an important role in disease diagnosis, which refers to the classification of sleep epochs into different sleep stages. Polysomnography (PSG), consisting of many different physiological signals, e.g.

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The biological role of Ten-11 translocation 2 (TET2) and the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in the development of extra-nodal natural killer/T-cell lymphoma (ENKTL) remains unclear. The level of 5mC and 5hmC was detected in 112 cases of ENKTL tissue specimens by immunohistochemical (IHC) staining. Subsequently, TET2 knockdown and the overexpression cell models were constructed in ENKTL cell lines.

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