Distinct network patterns emerge from Cartesian and XOR epistasis models: a comparative network science analysis.

Background: Epistasis, the phenomenon where the effect of one gene (or variant) is masked or modified by one or more other genes, significantly contributes to the phenotypic variance of complex traits. Traditionally, epistasis has been modeled using the Cartesian epistatic model, a multiplicative approach based on standard statistical regression. However, a recent study investigating epistasis in obesity-related traits has identified potential limitations of the Cartesian epistatic model, revealing that it likely only detects a fraction of the genetic interactions occurring in natural systems.

m6A methylation dynamically participates in the immune response against Vibrio anguillarum in half-smooth tongue sole (Cynoglossus semilaevis).

N6-methyladenosine (m6A) is the most prevalent RNA modification and a multifaceted regulator capable of affecting various aspects of mRNA metabolism, thereby playing important roles in numerous physiological processes. However, it is still unknown whether, when, and to what extent m6A modulation are implicated in the immune response of an economically important aquaculture fish, half-smooth tongue sole (Cynoglossus semilaevis). Herein, we systematically profiled and characterized the m6A epitranscriptome and transcriptome in C.

Diversity and Potential Metabolic Characteristics of Culturable Copiotrophic Bacteria That Can Grow on Low-Nutrient Medium in Zhenbei Seamount in the South China Sea.

Oligotrophs are predominant in nutrient-poor environments, but copiotrophic bacteria may tolerate conditions of low energy and can also survive and thrive in these nutrient-limited conditions. In the present study, we isolated 648 strains using a dilution plating method after enrichment for low-nutrient conditions. We collected 150 seawater samples at 21 stations in different parts of the water column at the Zhenbei Seamount in the South China Sea.

Comparative Study on Online Prediction of TP2 Rolled Copper Tube Wall Thickness Based on Different Proxy Models.

The wall thickness of the TP2 copper tube casting billet is not uniform after a three-roll planetary rotational rolling, which affects the wall thickness uniformity of the copper tube in the subsequent process. In order to study the influence of wall thickness at different positions of copper pipe after rolling on the wall thickness of copper pipe after joint drawing, an online ultrasonic test platform was used to measure the wall thickness of copper pipe after tying, and based on the test data, a finite element model of copper pipe billet was established, and the numerical simulation of joint drawing wall thickness was conducted. Based on the results of the ultrasonic testing experiment and finite element simulation, different neural network models were used to predict the joint tensile wall thickness with the data of the ultrasonic testing experiment as input and the results of finite element simulation as output.

Shallow-water Trapezioidea (Decapoda: Brachyura) from the South China Sea, including two new records, and notes on Tetralia glaberrima Herbst, 1790.

A collection of coral symbiotic crabs (Trapezioidea) from the South China Sea reports a total of 24 species, including 12 species of Trapeziidae (including one new record: Trapezia plana Ward, 1941), four species of Domeciidae, and eight species of Tetraliidae (including one new record: Tetralia brengelae Trautwein, 2007). Live color and mitochondrial cytochrome oxidase I (COI) sequence data of all species are provided.

Lebbeus dentatus n. sp. (Decapoda, Thoridae) described from a seamount of the Caroline Plate, NW Pacific.

Based on the female specimen collected from an unnamed seamount on the Caroline Plate in the NW Pacific, a new species of the thorid genus Lebbeus White, 1847, L. dentatus n. sp.

A new genus and one new species of the family Uristidae Hurley, 1963 (Amphipoda, Lysianassoidea) described from hydrothermal vent of the Okinawa Trough, NW pacific.

A new genus of the family Uristidae Hurley, 1963 is proposed, Liuiuristis gen. nov., with new species L.

Liquid-Solid Triboelectric Nanogenerator-Based DNA Barcode Detection Biosensor for Species Identification.

DNA barcode detection method is widely applied for species identification, which is imperative to evaluate the effect of human economic activities on the biodiversity of ecosystem. However, the wide utilization of existing detection biosensors is limited by bulky and expensive instruments, such as Raman spectroscopy and electrochemical station. Herein, a liquid-solid triboelectric nanogenerator (TENG)-based DNA barcode detection biosensor is proposed, which consists of water flow, fluid channel, and PDMS film attached by specifically designed capture probe.

Using high-frequency oscillations from brief intraoperative neural recordings to predict the seizure onset zone.

Background: While high-frequency oscillations (HFOs) and their stereotyped clusters (sHFOs) have emerged as potential neuro-biomarkers for the rapid localization of the seizure onset zone (SOZ) in epilepsy, their clinical application is hindered by the challenge of automated elimination of pseudo-HFOs originating from artifacts in heavily corrupted intraoperative neural recordings. This limitation has led to a reliance on semi-automated detectors, coupled with manual visual artifact rejection, impeding the translation of findings into clinical practice.

Methods: In response, we have developed a computational framework that integrates sparse signal processing and ensemble learning to automatically detect genuine HFOs of intracranial EEG data.

Anatomic Surface Measurement of the Lumbar Laminae for Safely Resection During Percutaneous Endoscopic Surgery: A Computed Tomography-Based 3-Dimensional Morphometric Study.

Objective: The aim of this study was to use computed tomography-based 3-dimensional morphometric imaging to precisely quantify the anatomic parameters of the lumbar laminae and increase the precision of laminar fenestration during percutaneous endoscopic spinal surgery.

Methods: Lumbar computed tomography data for the L1-L5 vertebrae of 62 patients (310 total vertebrae) were collected. Laminar width, height, thickness, and bilateral angle were measured in detail, and each parameter was compared and analysed.

Cell-Penetrating Peptides in infection and immunization.

Bacteria and viruses pose significant threats to human health, as drug molecules and therapeutic agents are often hindered by cell membranes and tissue barriers from reaching intracellular targets. Cell-penetrating peptides (CPPs), composed of 5-30 amino acids, function as molecular shuttles that facilitate the translocation of therapeutic agents across biological barriers. Despite their therapeutic potential, CPPs exhibit limitations, such as insufficient cell specificity, low in vivo stability, reduced delivery efficiency, and limited tolerance under serum conditions.

Construction of a novel amphiphilic peptide paclitaxel rod micelle: Demonstrating that the nano-delivery system shape can affect the cellular uptake efficiency of paclitaxel and improve the therapeutic efficacy for breast cancer.

Recent studies have shown that the morphology of nano-delivery systems has become a key factor affecting their anti-tumor effects. Although it has been demonstrated that rod-like nanoparticles are more easily absorbed by tumor cells, the application of rod-like nanoparticles is still limited by the lack of safe vector in vivo. In this study, a biocompatible amphiphilic peptide (IIQQQQ, IQ), was designed to form rod-like micelles.

Mentum, Mouth Floor, and Tongue Necrosis Following Hyaluronic Acid Injection for Chin Augmentation.

Hyaluronic acid injection for chin augmentation presents a minimally invasive technique that has garnered increasing popularity. Although the chin region is generally regarded as relatively safe with a lower likelihood of ischemic complications, it is imperative to recognize that severe adverse events can still arise due to variations in vascular or bone structures. This article documents a rare case of necrosis affecting the chin skin, floor of the mouth, and tongue after hyaluronic acid injection for chin augmentation, which was successfully managed with reconstituted hyaluronidase injection.

High-Performance Supercapacitive Pressure Sensors via Height-Grading Micro-Domes of Ionic Conductive Elastomer.

Soft capacitive sensors present numerous appealing characteristics, including simple structure, low power consumption, and fast response. However, they often suffer from low sensitivity and a limited linear sensing range. Herein, a concept is presented to enhance the sensitivity and linearity of supercapacitive pressure sensors by functionally grading the heights of macrodomes constructed from a highly elastic and ionic conductive elastomer made of poly(vinyl alcohol) and phosphoric acid (PVA/HPO).

Effects of saline-alkaline stress on metabolomics profiles, biochemical parameters, and liver histopathology in large yellow croaker (Larimichthys crocea).

China has several saline-alkaline bodies. Studies on the adaptation of fish in saline-alkaline conditions are important for the efficient utilization of such areas. In this study, we employed a comprehensive approach combining histopathological analysis, biochemical markers, and metabolomic profiling to examine the impact of saline-alkaline stress on the liver of the large yellow croaker (Larimichthys crocea).

SHP-1 alleviates acute liver injury caused by Escherichia coli sepsis through negatively regulating the canonical and non-canonical NFκB signaling pathways.

SHP-1, as a protein tyrosine phosphatase, plays a key role in inflammation-related diseases. However, its function and regulatory mechanism in the imbalance of inflammatory response and acute liver injury during sepsis are still unknown. Herein, we constructed a murine model of Escherichia coli (E.

Senescent CD8+ T cells: a novel risk factor in atrial fibrillation.

Aims: Immune cell alterations may play a role in the development of atrial fibrillation (AF). Our objective was to comprehensively characterize immune cells in AF, and investigate the potential mechanisms.

Methods And Results: Single-cell RNA sequencing and multicolor flow cytometry revealed that T cells constituted the most significant subset alterations in AF, and senescent CD8+ T cells were AF-associated subset.

Microfluidic synthesis and accurate immobilization of low-density QD-encoded magnetic microbeads for multiplex immunoassay.

Magnetic-fluorescent microbeads have been widely used in the multiplex detection of biological molecules. The traditional method relies on flow cytometry to decode and analyze the microbeads. Alternative strategies that employ immobilized microbeads on a plane and involve fluorescence imaging to analyze the microbeads have been proposed.

Revealing Local Grain Boundary Chemistry and Correlating it with Local Mass Transport in Mixed-Conducting Perovskite Electrodes.

Grain boundary (GB) mass transport, and chemistry exert a pronounced influence on both the performance and stability of electrodes for solid oxide electrochemical cells. Lanthanum strontium cobalt ferrite (LSCF6428) is applied as a model mixed ionic and electronic conducting (MIEC) perovskite oxide. The cation-vacancy distribution at the GBs is studied at both single and multi-grain scales using high-resolution characterization techniques and computational approaches.

Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness.

Language is supported by a distributed network of brain regions with a particular contribution from the left hemisphere. A multi-level understanding of this network requires studying its genetic architecture. We used resting-state imaging data from 29,681 participants (UK Biobank) to measure connectivity between 18 left-hemisphere regions involved in multimodal sentence-level processing, as well as their right-hemisphere homotopes, and interhemispheric connections.

Disulfiram Upgrades the Radiosensitivity of Osteosarcoma by Enhancing Apoptosis and P53-Induced Cell Cycle Arrest.

The prognosis of osteosarcoma has not been improved for decades. As radioresistance is one of the major reasons, effective radiotherapy sensitization drugs need to be discovered. HOS and K7M2 osteosarcoma cell lines were treated with disulfiram (DSF) and radiation to assess cell viability, proliferation, migration ability, apoptosis level, ROS and Ca2+ level, and cell cycle in vitro.