Exploration of Circadian Clock-Related Genes in the Pathogenesis of Psoriatic Arthritis to Identify Potential Therapeutic Targets From Multi-Omics Insight: A Mendelian Randomization Study.

Background: Circadian rhythms have been shown to play a significant role in the etiology and progression of immune-related morbidities, including cancer and autoimmune diseases. As an autoimmune disorder, psoriatic arthritis (PsA) has been underexplored in the context of circadian rhythms. This study aimed to explore the relationship between circadian rhythm and PsA.

A periungual eccrine poroma masquerading as amelanotic melanoma: a case report.

Background: Eccrine poroma (EP) is a benign cutaneous neoplasm that originates from the acrosyringium of the eccrine sweat duct. EP can be found on any skin area with sweat glands and typically occurs on the palmoplantar areas. They usually present as solitary, asymptomatic, well-circumscribed, smooth or verrucous papules or nodules that range in color from skin-colored to red or brown.

Optimization on cell lysis and capture process of human adenovirus type 5 produced in suspension HEK293 cells.

Adenovirus (Adv) is increasingly recognized for its significance in the fields of gene therapy and viral vector vaccines. The diverse applications in clinical trials and fundamental research necessitate the development of environmentally and economically sustainable purification processes that are straightforward and scalable for both academic and industrial contexts. In the initial segment of this study, we evaluated the lysis efficiency of polysorbate 20 (PS20) in comparison to polysorbate 80 (PS80).

Identifying therapeutic targets for kidney stone disease through proteome-wide Mendelian randomization and colocalization analysis.

Kidney stone disease (KSD) is facing rising global prevalence and recurrence rates. Mendelian randomization aids in drug repurposing and the discovery of therapeutic targets. This study utilized Mendelian randomization (MR) to identify protein targets for KSD treatment and assess potential adverse drug reactions.

In Situ Construction of Bimetallic Selenides Heterogeneous Interface on Oxidation-Stable TiCT MXene Toward Lithium Storage with Ultrafast Charge Transfer Kinetics.

TiCT (MXene) is widely acknowledged as an excellent substrate for constructing heterogeneous structures with transition metal chalcogenides (TMCs) for boosting the electrochemical performance of lithium-ion storage. However, conventional synthesis strategies inevitably lead to poor electrochemical charge transfer due to TiCT-derived TiO at the heterogeneous interface between TiCT and TMCs. Here, an innovative in situ selenization strategy is proposed to replace the originally generated TiO on TiCT with metallic TiSe interphase, clearing the bottleneck of slow charge transfer barrier caused by MXene oxidation.

Syringic acid suppresses Cutibacterium acnes-induced inflammation in human keratinocytes via regulating the NLRP3/caspase-1/IL-1β signaling axis by activating PPARγ/Nrf2-antioxidant pathway.

Background: Our previous studies have demonstrated a strong relationship betweenCutibacterium acnes(C. acnes), oxidative stress, and acne inflammation. Syringic acid (SA) is a plant widely used for its antimicrobial, anti-inflammatory, and antioxidant activities, but lacking data on acne.

Pulmonary Actinomycosis in a 65-Year-Old Female with Poor Oral Dentition.

Pulmonary actinomycosis is an uncommon clinical entity that can be challenging to diagnose due to its non-specific symptomatology. Misdiagnosis and delayed treatment may result in invasive procedures and extended antimicrobial treatment courses. We report a case involving a 65-year-old female with poor oral dentition admitted for acute respiratory failure subsequently found to have a left-sided pleural effusion and perihepatic abscess formation.

Breast Cancer With HER2 Immunohistochemical Score 2 and Average HER2 Signals/Cell 6 or More and HER2/CEP17 Ratio Less Than 2 ('ISH Group 3'): A Multi-Institutional Cohort Analysis Emphasizing Outcome and Molecular Subtype.

Breast cancer (BC) with average human epidermal growth factor receptor 2 (HER2) signals/cell ≥6 and HER2/chromosome enumeration probe 17 (CEP17) ratio <2 (in situ hybridization [ISH] group 3) is very rare, accounting for 0.4% to 3.0% of cases sent for the dual-probe ISH assay.

Recent advances in MXene-based nanocomposites for supercapacitors.

MXene materials have become a competitive candidate for electrochemical energy storage due to their unique two-dimensional layered structure, high density, metal-like conductivity, fast ion intercalation, tunable surface terminal groups, and good mechanical flexibilities, showing unique application advantages in the field of supercapacitors. With widely research of MXene in energy storage applications, plenty of studies in synthesis strategies of MXene, including etching, intercalation and exfoliation processes, and its charge storage mechanism in supercapacitors have been conducted. However, the restacking of two-dimensional MXene nanosheets severely affects their electrochemical performance.

Lutein attenuates Propionibacterium acnes-induced inflammation by inhibiting pyroptosis of human keratinocyte cells via TLR4/NLRP3/Caspase-1 pathway.

Background: Previous studies found Propionibacterium acnes (P. acnes) has a strong association with acne inflammation and cell pyroptosis. Because of the various side effects of current acne medicines, it is important to explore alternative drugs with anti-inflammatory activity against P.

Cationic intermediates assisted self-assembly two-dimensional TiCT/rGO hybrid nanoflakes for advanced lithium-ion capacitors.

Two-dimensional (2D) material MXenes have been intensively concerned in energy-storage field due to these unique properties of metallic-like conductivity, good hydrophilicity and high volumetric capacity. However, the self-restocking of ultra-thin 2D materials seriously hinders these performances, which significantly inhibits the full exploitation of MXenes in the field of energy storage. To solve this issue, a strategy to prepare delaminated TiCT (MXene) nanoflakes/reduced graphene oxide (rGO) composites is proposed using the electrostatic self-assembly between positively charged TiCT with tetrabutylammonium ion (TBA) modification and negatively charged graphene.

Unveiling the Interface Structure of the Exsolved Co-Fe Alloy Nanoparticles from Double Perovskite and Its Application in Solid Oxide Fuel Cells.

Exsolution of catalytic nanoparticles (NPs) from perovskites has arisen as a flexible method to develop high-performance functional materials with enhanced durability for energy conversion and catalytic synthesis applications. Here, we unravel the interface structure of the exsolved alloy nanoparticles from the double perovskite substrate on the atomic scale. The results show that the Co-Fe alloy NPs exsolved topologically from the {100} facets terminations of the SrFeMoCoO (SFMC) double perovskite along ⟨100⟩ directions exhibiting the same orientation and identical crystal structure.

[Structural characteristics and catalytic cycle of dihydroorotate dehydrogenase-a review].

Dihydroorotate dehydrogenase is a flavin-dependent mitochondrial enzyme to catalyze the fourth step of the de novo synthesis of pyrimidine and to oxidize dihydroorotate to orotate. By selectively inhibiting dihydroorotate dehydrogenase, thereby inhibiting pyrimidine synthesis, the enzyme has been developed for the treatment of cancer, autoimmune diseases, bacterial or viral infections, parasitic diseases and so on. The development of inhibitory drugs requires a detailed understanding of the structural characteristics and catalytic cycle mechanism of dihydroorotate dehydrogenase.

Purification, characterization, antioxidant, and antitumor activity of polysaccharides isolated from silkworm cordyceps.

Two new water-soluble polysaccharide fractions (SCP II-1 and SCP II-2) were obtained from silkworm cordycepsusing DEAE Sepharose FF and Superose 6 columns chromatography. The characterization of their basic structure was studied by high performance liquid chromatography, high performance ion chromatography, infrared spectroscopy and atomic force microscope (AFM). The results showed that the molecular weight of SCP II-1 and SCP II-2 were 35.

Metal-release potential from iron corrosion scales under stagnant and active flow, and varying water quality conditions.

The release of potentially toxic metal ions from corrosion scales formed on pipe surfaces is of great concern for water quality in drinking water distribution systems (DWDS). This study examined the effects of alkalinity, chloride, and sulfate on metal release from corrosion scales sampled from a corroded iron pipe. Jar tests and recirculation pipe systems were used to investigate the metal-release potential during stagnant and active flow conditions.

Liubao Insect tea polyphenols prevent HCl/ethanol induced gastric damage through its antioxidant ability in mice.

The aim of this study was to study the preventive effects of polyphenols extracted from Liubao Insect tea on gastric injury. The content of Liubao Insect tea polyphenols (LITP) was 72.36% by ion precipitation extraction method.

Mutual regulation of MDM4 and TOP2A in cancer cell proliferation.

MDM4 and topoisomerase IIα (TOP2A) are overexpressed in various human cancers. MDM4 acts as an oncoprotein which promotes cancer progression by inhibiting tumor suppressor p53. As a DNA replication- and cell division-regulating enzyme, TOP2A is the main target of many anticancer therapy regimens; however, the exact role of TOP2A in cancer remains elusive.

Rational design of nano-architecture composite hydrogel electrode towards high performance Zn-ion hybrid cell.

In this paper, we developed a novel Zn-ion hybrid cell based on a graphene-conducting polymer composite hydrogel (capacitor-type) cathode and a zinc metal (battery-type) anode. The pseudocapacitive-type cathode materials can effectively boost the capacity of Zn-ion hybrid cell compared to that of electrical double layer cathode materials. In particular, the composite hydrogel with rational designed three-dimensional (3D) nano-architecture combining 3D porous nanostructure with hydrogel, can significantly enlarge the active interfaces between the electrode and electrolyte.

Binder-free 2D titanium carbide (MXene)/carbon nanotube composites for high-performance lithium-ion capacitors.

Two-dimensional (2D) MXenes have a very good application prospect in the field of electrochemical energy storage due to their metallic conductivity, high volumetric capacity, mechanical and thermal stability. Herein, we report the preparation of titanium carbide (Ti3C2Tx)/carbon nanotube (CNT) flexible self-supporting composite films by vacuum filtration. The CNTs can effectively prevent Ti3C2Tx from stacking and improve the electrochemical performance.

Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice.

A novel small-molecule anthraquinone (AQ) analogue, AQ-101, which was synthesized through chemical modification of the core structures of rhein, exhibited potent anticancer activity. In the present study, we evaluated the cancer-inhibiting mechanism of AQ-101 and tested the therapeutic potential of this compound for treating cancer in mice. We found that AQ-101 was able to induce MDM2 protein degradation through a self-ubiquitination and proteasome-mediated mechanism.

Deguelin induced differentiation of mutated NPM1 acute myeloid leukemia in vivo and in vitro.

Nucleophosmin (NPM1), a restricted nucleolar localization protein, shuttles between the nucleus and the cytoplasm. Mutated (Mt)-NPM1 protein, which has aberrant cytoplasmic dislocation of nucleophosmin, occurs in approximately one-third of acute myeloid leukemia cases. Deguelin, a rotenoid isolated from several plant species, is a strong antitumor agent.

Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment.

MDM2 and XIAP are mutually regulated. Binding of MDM2 RING protein to the IRES region on XIAP mRNA results in MDM2 protein stabilization and enhanced XIAP translation. In this study, we developed a protein-RNA fluorescence polarization (FP) assay for high-throughput screening (HTS) of chemical libraries.

High-Performance Anode Material Sr2FeMo0.65Ni0.35O6-δ with In Situ Exsolved Nanoparticle Catalyst.

A metallic nanoparticle-decorated ceramic anode was prepared by in situ reduction of the perovskite Sr2FeMo0.65Ni0.35O6-δ (SFMNi) in H2 at 850 °C.