Publications by authors named "Sha Dou"
Article Synopsis
- Near-infrared fluorescence (NIRF) imaging is effective for guiding surgery, and the study focuses on creating a tumor-specific fluorescent probe using cetuximab, which targets the EGFR prevalent in epithelial ovarian cancer (EOC).
- The research involved assessing EGFR levels in EOC using a xenograft model and employing the cetuximab-Cy7 probe for in vivo imaging, with control groups for comparison.
- Results showed high EGFR expression in EOC tissues, correlating with favorable outcomes, and confirmed that cetuximab-Cy7 effectively detected tumors, suggesting an optimal imaging window of 24-96 hours post-injection.
Unlabelled: High-grade serous cancer (HGSC) is the most common subtype of ovarian cancer. HGSC is highly aggressive with poor patient outcomes, and a deeper understanding of HGSC tumorigenesis could help guide future treatment development. To systematically characterize the underlying pathologic mechanisms and intratumoral heterogeneity in human HGSC, we used an optimized single-cell multiomics sequencing technology to simultaneously analyze somatic copy-number alterations (SCNA), DNA methylation, chromatin accessibility, and transcriptome in individual cancer cells.
View Article and Find Full Text PDFOvarian cancer is a leading cause of death among gynecological malignancies, and novel therapies are urgently needed. Here we report preliminary findings on the potential safety and efficacy of 6B11-OCIK, an adoptive cell therapy of autologous T cells induced by the humanized anti-idiotypic antibody 6B11 minibody plus dendritic cells and cytokines, against platinum-resistant recurrent or refractory ovarian cancer in three patients. We found that 6B11-OCIK treatment was safe and well tolerated after five cycles of intravenous infusion with an initial dose of 1-2×10 cells and a dose-climbing strategy.
View Article and Find Full Text PDFObjective: Hematogenous metastasis is essential for the progression of ovarian cancer (OC), and circulating tumor cells (CTCs) are part of the metastatic cascade. However, the detection rate of CTC is low due to the use of less sensitive detection methods. Therefore, this study aimed to detect CTCs and circulating tumorigenic endothelial cells (CTECs) in patients with OC using subtraction enrichment and immunostaining and fluorescence hybridization (SE-iFISH).
View Article and Find Full Text PDFProblem: Evaluate the response rate of glucocorticoid (GC) and/or immunoglobulin (IVIg) therapy in severe thrombocytopenia of immune thrombocytopenia (ITP) pregnant patients and the influence on maternal and neonatal outcomes.
Method Of Study: This is a prospective observational cohort study. Pregnant ITP patients with platelet count less than 30 × 10 /L and their newborn infants participated in this research.