[Safety of tadalafil in patients with cardiovascular comorbidities].

Tadalafil is a drug from the phosphodiesterase-5 inhibitors (PDE-5) group, which is used to treat erectile dysfunction (ED), lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH) and ED with LUTS in patients with BPH. The efficacy and safety of tadalafil were reviewed. The focus was on cardiovascular safety of tadalafil due to frequent cardiovascular comorbidities in patients with ED.

[Molecular aspects of the impact of the Speroton complex on the male fertility in idiopathic infertility].

Aim: To characterize the effect of the Speroton complex on the free radical homeostasis in the ejaculate of males of infertile couples and the likelihood of pregnancy in partners.

Materials And Methods: The study group comprised 30 men aged between 26 and 43 years (mean 33 +/- 4.8 years) with idiopathic infertility.

Dioxins in the semen of men with infertility.

The purpose of the present study was to assess ejaculate contamination by polychlorinated dibenzo-p-dioxins/furans in male infertility. The database of 168 infertile and 49 fertile men was included in the study. Dioxin content was determined using gas chromatography/high-resolution mass spectrometry (GC/HRMS).

[Effects of L-carnitine on ejaculate parameters in males from infertile couples].

The aim of our investigation was detection of molecular mechanisms of an antioxidant action of L-carnitine (a transmembrane carrier of long-chain fatty acids) in idiopathic pathospermia. We treated 60 males from infertile couples with karniton (1 g/day). L-carnitine impact on ejaculate antioxidant status was assessed by registration of chemiluminescence and total antioxidant activity by colorimetric method according to changes in the color of ABTS chromogen.

[Molecular markers of ejaculate fertility in officers of Internal Affairs Ministry Special Forces, if under battle stress].

The article presents results of studies in males participated in anti-terrorist military operations in local conflict areas. Findings are intact general spermogram parameters with lower serum and/or ejaculate levels of glycodeline and inhibin B--that is a precondition for high risk reproductive disorders under battle stress.

[Oxidative stress of spermatozoa in pathogenesis of male infertility].

Oxidative stress is a common pathology seen in approximately half of all infertile men. Peroxides causing infertility are generated by sperm and seminal leukocytes. Oxidative stress occurs when production of potentially destructive reactive oxygen species exceeds natural antioxidant defenses resulting in cellular damage.

[Effect of propolis bioflavonoids on lipoperoxidation processes in the gonads of rats intoxicated by polychlorinated biphenyls].

The check of a hypothesis about possible participation oxidative stress to infringement of fertility is spent at a poisoning polychlorbefeniles. Increased ability to generation of reactive oxygen species by morphologically defective spermatozoa has been revealed. There is a decrease of total antioxidizing activity of testis.

Gonadotoxic effect of polychlorobiphenyls.

The distribution of polychlorobiphenyls (environmental pollutants) in the reproductive organs and fatty tissues of rats was analyzed and selective accumulation of the toxicants in the epididymis, but not in the ovaries, was demonstrated. Reduction of the fertilizing activity of the ejaculate after chronic exposure to polychlorobiphenyls was detected. Mechanisms of spermatogenic dysfunction under conditions of high technogenic load are discussed.

[Spermicidal properties of major environmental pollutants assigned to polychlorbiphenyls class].

The authors considered accumulation of environmental pollutants assigned to polychlorbiphenyls class in fat tissue and reproductive organs of male rats, discovered major accumulation of the pollutants in epididymis, demonstrated significant changes in cellular contents and functional properties of sperm.

[Spermatogenesis impairment by polychlorbiphenyls: endocrine and paracrine mechanisms of the damage].

Possible role of changed contents of certain cytokines in the genesis of reproductive disorders was studied in an experiment with rats intoxicated chronically by polychlorbiphenyl (PCB) ecopollutants at the total doses of 0.3 g/kg of the body weight (0.05 LD50 and 3 g/kg of the body weight (0.

[Effect of 2,4-D ecotoxicants on spermatogenesis and fertility of albino rats].

Characteristics of spermatogenesis, morphometric changes in the Leydig's and Sertoli's cells, and fertility of albino rats exposed to various doses of 2.4-D were investigated. Chronic injection of the herbicide led to transitional sterility against pronounced disorders of spermatogenesis, hyperplasia of sertolicytes and predominance of low-active forms of the Leydig's cells.

[Morphofunctional characteristics of the testis of albino rats exposed to dioxin-containing herbicide 2,4-D].

Endocrine system of the gonads of white rats after subacute poisoning with 2,4-D was studied. Signs of increased steroidogenesis in Leydig cells, a decrease of plasma testosterone concentration and decrease of the gonad sensitivity to chorionic gonadotropin were observed.

[The effect of the dioxin-containing herbicide 2,4-D on the hormonal status of experimental animals].

The article presents studies of hormonal state in rats under daily or 20-day peroral administration of variable doses of 2,4-D herbicide containing dioxine. Changed levels of thyroid hormones, insulin, cortisol, testosterone and estradiol appeared to be divergent and dose-dependent, proving direct toxic effects of the herbicide in endocrine organs, altered hormonal effects in target organs and disorders of peripheral hormonal metabolism.

[The nicotinamide coenzyme system in experimental burn disease during prepubescence].

Distinct impairments were observed in metabolism of nicotinamide coenzymes in liver tissue of preadolescent rats with severe thermic burns: a decrease in total content of the coenzymes, a decrease in content of oxidized forms and elevation of reduced derivatives, inhibition of biosynthesis and stimulation of the nicotinamide coenzymes catabolism, especially high during acute period of burns. Nicotinamide, administered at a dose of 50 mg/kg into animals, was shown to correct the coenzymes content and activity of glyceraldehydephosphate dehydrogenase in liver tissue of rats with burns.