[The vaccinal prophylaxis of hepatitis B among children born to mothers with persistent HBs-antigenemia].

In Uzbekistan and Moldova 542 children born of HBsAg carriers were immunized against hepatitis B (with vaccine Engerix B according to the immunization schedule of 4 injections). Anti-HBs antibodies in protective titers were detected by EIA and RIA techniques in 76.7% of children aged 4-5 months after the 3rd injection, in 95.

[The role of oligomeric structure of human serum albumin during its interaction with polyalbumin receptors in blood serum of patients with viral hepatitis B].

Several oligomers of human blood serum albumin modified by glutaraldehyde differ in their binding ability to polyalbumin receptors in blood serum of patients with viral hepatitis B. Erythrocytes containing the albumin tetramer are able to agglutinate, while the red blood cells coated with dimer or monomer are deprived of this property. At the same time, the albumin dimers and monomers neutralize agglutination of the erythrocytes containing the complete pool of modified albumin in membranes although their effect is distinctly lower than that of tetramer.

[Interferon-inducing activity of amixin and its effect on the interferon status].

The national preparation amixine induces interferon (IF) production in most of the people who have background values of serum IF. When the initial values of serum IF are high, after administration of amixine they decline to the background ones. A certain group of subjects (approximately 25%) is not sensitive to amixine.

[Electron microscopy study of the cooperative interaction of immunocompetent cells in the liver of patients with chronic active hepatitis B].

Electron microscopic examinations of liver biopsies from patients with chronic active hepatitis B (CAH) revealed close contact of macrophages with lymphocytes in the lumen of sinusoids, penetration of lymphocytes into the liver bulk and connection of their processes with hepatocytes. Hydropic degeneration of hepatocytes was detected. The above results indicate that cooperation of the immunocompetent cells with lymphocyte killer effect is one of the pathogenetic mechanisms in the formation of a complicated infectious process in CAH.