Publications by authors named "Sh Alizadeh"
Objective: Acute myeloid leukemia (AML) is characterized by abnormalities of differentiation and growth of primary hematopoietic stem cells (HSCs) in the blood and bone marrow. In many studies, miR-625-5p has been shown to inhibit downstream pathways from affecting the metastasis and invasion of the integrin-linked kinase (ILK) signaling pathway. It has been proved that the expression of miR-625-5p decreases in AML cell lines.
View Article and Find Full Text PDFObjective: Whereas prostate cancer (PrCa) may be unresponsive or moderately responsive to radiation therapy (RT)- most common modality for treatment of PrCa- patients must receive a high dose of RT In order to achieve appropriate tumour control. However, this increase in radiation dose may lead to severe adverse effects in normal tissues. Sensitization of PrCa to radiation provides an alternate approach to improve the therapeutic efficacy of RT.
View Article and Find Full Text PDFMir-55 inhibition can reduce cell proliferation and induce apoptosis in Jurkat (Acute T cell Leukemia) cell line.
Iran J Ped Hematol Oncol
January 2015
Article Synopsis
- MicroRNAs, like miR-155, are small RNA molecules that regulate gene expression and play key roles in processes such as cell proliferation and apoptosis, impacting immune response and inflammation.
- This study focused on the effects of inhibiting miR-155 in Jurkat cells, using various concentrations of an inhibitor to assess cell sensitivity, measure caspase-3 activity, and analyze miR-155 expression through QRT-PCR.
- Results showed that higher concentrations of the miR-155 inhibitor significantly increased caspase-3 activity, suggesting that targeting miR-155 could induce apoptosis and potentially serve as a therapeutic approach in cancer treatment.
Current understanding in diagnosis and management of factor XIII deficiency.
Iran J Ped Hematol Oncol
June 2014
Factor XIII or "fibrin-stabilizing factor," is a transglutaminase circulates in the blood circulation as a hetero tetramer with two catalytic A subunits and two carrier B subunits. This important coagulation factor has a crucial role in clotting cascade and produces strong covalent bonds between soluble formed fibrin monomers during coagulation. This stable cross linked fibrin strands are resistanttodegradationby thefibrinolyticsystem that enablesthe bodyto stoppotential bleeding episodes.
View Article and Find Full Text PDFEffect of thyroid dysfunctions on blood cell count and red blood cell indice.
Iran J Ped Hematol Oncol
February 2014
Background: Thyroid hormones have a crucial role in metabolism and proliferation of blood cells. Thyroid dysfunction induces different effects on blood cells such as anemia, erythrocytosis leukopenia, thrombocytopenia, and in rare cases causes' pancytopenia. It also alter RBC indices include MCV, MCH, MCHC and RDW.
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