[Liver microsome monooxygenase activity in rats under the effects of organochlorine and organophosphorus pesticides and different nutrition background].

The influence of acute and chronic intoxication with a mixture of lindane and trichlorometaphos-3 on monooxygenases of rat liver was studied in rats insufficiently provided with lysine and vitamins A, C and E. It has been found that in the presence of poly-nutrient insufficiency monooxygenase induction develops more rapidly and to a greater extent than in the presence of balanced nutrition. Chronic intoxication with the pesticide mixture leads to monooxygenase system induction under both regimens of nutrition.

[Metabolism of the pesticide trichlorometaphos-3 and its effect on the monooxygenase system depending upon the supply of lysine, methionine, threonine and vitamins A, B and C].

Metabolism of organophosphate pesticide trichlorometaphos-3 and its effect on liver monooxygenase system were studied in male rats of WAG strain, maintained on a diet deficient in lysine, methionine, threonine and vitamins A, C, E. Long-term deficiency of these essential nutrients led to inhibition of monooxygenase induction in acute intoxication with pesticide (150 mg/kg) and to restriction of the induction in chronic intoxication (3 mg/kg) within 3 and 6 months. As a result of the intoxication highly toxic intermediate 2,4,5-trichlorophenol was accumulated in liver tissue of the animals kept on the disbalanced diet.

[Effect of acute and chronic lindane poisoning on the function of the liver microsome mono-oxygenase system in rats maintained on a diet deficient in lysine, methionine, threonine and vitamins A, C and E].

Polynutrient deficiency in essential amino acids and vitamins A, C and E led to induction of liver tissue microsomal monooxygenase system in male rats of WAG strain within first 2 hrs and to inhibition of the induction within the subsequent hours after a single dose administration of a pesticide lindane (18 mg/kg) as compared with control animals maintained on a normal diet. The deficiency in essential nutrients caused also a delay in the monooxygenase induction in rats treated daily within 3 months with lindane at a dose of 0.9 mg per kg of body mass.

[Effect of lysine, threonine, methionine and vitamin A, C and E deficiency on the liver microsome enzyme system responsible for metabolizing foreign compounds in the rat].

It has been demonstrated that the deficiency of 3 essential amino acids (lysine, threonine and methionine) combined with polyhypovitaminosis A, C and E for 2 months leads to a decrease in the para-hydroxylase and N-demethylase activity in rat liver microsomes. The content of cytochromes P-450 and b5 was also reduced as compared to that in animals given balanced nutrition. However, in such a polynutrient deficiency, the activity of microsomal enzymes was induced by phenobarbital to a greater degree than in balanced nutrition.