[Clinico-morphological characteristics of esthesioneuroblastoma with extensive dissemination of the neoplastic process].

Eight disseminated esthesioblastomas were investigated. The specific features of these cases were: prolonged development of the disease prior to correct diagnosis (up to 2 years), tumor dissemination outside the nose and paranasal sinuses, and mixed morphological changes indicating various tumor types.

[The generalized form of Rendu-Osler-Weber disease (a practical case)].

The article presents clinical and pathomorphological findings related to a case of the Rendu-Osler-Weber disease and demonstrates the difficulties of its differential diagnosis.

[Hormonal induction of liver tyrosine aminotransferase in animals with chronic poisoning by hepatotropic poisons].

A study has been made of the effect of ethanol and CCl4 on hormonal induction of tyrosine aminotransferase in mouse liver. Both the hepatotropic poisons administered for a long time lose the induction effect and considerably reduce the same effect exerted by hydrocortisone. Microscopic study has revealed fatty dystrophy of the liver cells and even the formation of the areas of necrosis as a result of administering CCl4.

Quantitative histochemical estimation of the DNA content of the main histological types of lung cancer, with particular reference to the diagnosis of the degree of differentiation.

The results of microspectrophotometric measurements of the content of DNA of the cell nuclei developed in the zones of growth of 52 neoplasms of the lung of different histological types and degree of differentiation are shown. It was found that the growth of anaplasia of the tumour tissue to be characterized by increased "DNA Accumulation Index" and increased polyploidy. The authors think that quantitative determination of the DNA may be of value as an objective diagnostic test of malignization and degree of differentiation of lung cancer.

The microspectrophotometric research of the content of ascorbic acid in carcinomas of the uterine cervix.

Taking into consideration the fact that the ascorbic acid takes an active part in the process of growth and reproduction of the cells, the authors have undertook the microspectrophotometric research of its content in 27 different structure cancerous tumours of the uterous cervix. The result of the research showed the decrease of the quantity of ascorbic acid in cancerous tumours of the uterous cervix in compare with norm. The content of ascorbic acid in carcinomas cancerous tumours of the uterine cervix depends on the degree of differentiation and histogenesis of the neoplasm.

[Microspectrophotometric study of the content of various metabolites in cervical cancer].

The composite microspectrophotometric study of the content of DNA, PAS-positive, alcian-positive substances, lipids, and the activity of succinate dehydrogenase and ascorbic acid in the cervical epithelium normally and in cancer tumors showed preinvasive forms of cancer to be characterized by increased polyploidy, content of DNA and lipids, and increased activity of succinate dehydrogenase, and decreased content of glycogen, acid mucopolysaccharides and ascorbic acid. Invasive forms of cancer are characterized by more marked changes in these values.