Publications by authors named "Sg Edwards"

Unlabelled: Wheat ( L.), a vital cereal crop, provides over 20% of the total calories and protein in the human diet. However, , the pathogen responsible for Fusarium head blight (FHB), poses a significant threat to wheat production by contaminating grains with harmful mycotoxins.

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  • Claviceptaceous endophytic fungi form beneficial partnerships with cool-season grasses, enhancing plant protection and stress tolerance.
  • These fungi produce bioactive alkaloids that defend host plants against herbivores, while also impacting plant-parasitic nematodes through direct paralysis or death and by stimulating plant immunity.
  • Understanding the specific interactions between grass genotypes and endophyte strains is crucial for selecting effective grass-endophyte pairings to combat different nematode species.
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Objective: The aim of this study was to retrospectively evaluate vision outcomes of dogs with primary angle closure glaucoma (PACG) that underwent Ahmed valve gonioimplantation (AVG) followed by lensectomy and endolaser cyclophotocoagulation (ECP) with or without bleb resection after AVG failure.

Procedure: Medical records from 2008 to April 2022 were reviewed. All patients selected had an AVG performed first.

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  • People living with HIV have a higher chance of reactivating Chagas disease, which is often overlooked.
  • There was previously no data on Chagas disease prevalence in UK HIV clinics, prompting a screening initiative.
  • In a screening of 86 patients, no positive cases were found, but clinician awareness led to the identification of one seropositive patient, demonstrating the feasibility of routine screening despite its labor-intensive nature.
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Blue copper proteins are models for illustrating how proteins tune metal properties. Nevertheless, the mechanisms by which the protein controls the metal site remain to be fully elucidated. A hindrance is that the closed shell Cu(I) site is inaccessible to most spectroscopic analyses.

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  • The culture media currently used for isolating a specific spp. do not effectively select for it.
  • A range of five fungicides was tested to see if they could act as selective inhibitors for isolating the spp. from soil and plants.
  • Ultimately, fluxapyroxad showed some promise, but overall, no fungicides effectively improved selectivity, with Czapek Dox propiconazole dichloran agar outperforming Komada's media for detecting the spp. in plant samples.
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  • High levels of mycotoxins, particularly HT-2 and T-2 toxins, have been frequently found in oat grain in Norway, prompting a study on how tillage operations affect their presence.
  • Tillage trials in southeast Norway showed that grain from ploughed plots contained lower levels of these mycotoxins compared to harrowed plots, indicating that more intensive tillage can reduce contamination risks.
  • While no significant effect of tillage was observed on DNA concentration in harvested grain, considerable amounts of both DNA and mycotoxins were still detected, suggesting different survival and dispersal characteristics among the involved organisms.
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The World Health Organization has defined long COVID-19 (LC) as a condition that occurs in individuals with a history of SARS-CoV-2 infection who exhibit persistent symptoms after its acute phase that last for at least two months and cannot be explained by an alternative diagnosis. Since we had previously reported residual viral antigens in tissues of convalescent patients, we aimed to assess the presence of such antigens in long COVID tissues. Here, we established the presence of the residual virus in the appendix, skin, and breast tissues of 2 patients who exhibited LC symptoms 163 and 426 days after symptom onset.

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It is considerably harder to generalize identity across different pictures of unfamiliar faces, compared with familiar faces. This finding hints strongly at qualitatively distinct processing of unfamiliar face stimuli-for which we have less expertise. Yet, the extent to which face selective versus generic visual processes drive outcomes during this task has yet to be determined.

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  • The Norwegian cereal industry faces challenges from head blight (FHB) pathogens, which produce mycotoxins like deoxynivalenol (DON) and T-2 toxins (T2 and HT2) in oats.
  • This study aimed to evaluate Nordic spring oat varieties based on their mycotoxin content and the DNA of the fungal species producing them, highlighting the significant impact of FHB resistance on mycotoxin levels in grains.
  • Findings showed that oat varieties resistant to FHB had lower mycotoxin levels, emphasizing the need for separate testing for different mycotoxins to effectively screen for FHB resistance in oat breeding.
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  • Fusarium head blight (FHB) is a significant disease affecting small grain cereals globally, leading to lower yields and mycotoxin contamination, particularly with deoxynivalenol (DON).
  • Cereal growers use various control methods for FHB, mainly relying on fungicides during flowering, with current treatments mainly involving triazole chemistry.
  • A study tested a new co-formulation of pydiflumetofen and prothioconazole, finding it more effective than standard fungicides in controlling FHB and DON across multiple application timings, thereby enhancing IPM flexibility and reducing resistance risk.
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  • Norwegian oats are significantly affected by deoxynivalenol (DON), with weather conditions around flowering influencing DON levels.
  • A mathematical model was created to predict growth stages of spring oats, allowing researchers to analyze weather data linked to DON content.
  • The study found that warmer weather during sowing and cooler, more humid conditions leading up to flowering contribute to higher DON levels in oat grains.
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Background: Surgical treatment of scaphoid nonunion has evolved over the years to include a variety of procedures and techniques involving a number of vascularized and nonvascularized bone grafting options and fixation strategies. Volar plating of scaphoid nonunions with use of pure cancellous nonvascularized autograft is a safe and effective treatment method with good functional outcomes and union rates.

Description: Volar plating of the scaphoid nonunion is performed via a volar approach, with debridement and reduction of the nonunion site.

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Personal data is ubiquitous in the digital world, can be highly valuable in aggregate, and can lead to unintended intrusions for the data creator. However, individuals' expressions of concern about exposure of their personal information are generally not matched by their behavioural caution. One reason for this mismatch could be the varied and intangible value of personal data.

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When two people look at the same object in the environment and are aware of each other's attentional state, they find themselves in a shared-attention episode. This can occur through intentional or incidental signaling and, in either case, causes an exchange of information between the two parties about the environment and each other's mental states. In this article, we give an overview of what is known about the building blocks of shared attention (gaze perception and joint attention) and focus on bringing to bear new findings on the initiation of shared attention that complement knowledge about gaze following and incorporate new insights from research into the sense of agency.

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The transformation of quiescent keratocytes to activated fibroblasts and myofibroblasts (KFM transformation) largely depends on transforming growth factor beta (TGFβ) signaling. Initiation of the TGFβ signaling cascade results from binding of TGFβ to the labile type I TGFβ receptor (TGFβRI), which is stabilized by the 90 kDa heat shock protein (Hsp90). Since myofibroblast persistence within the corneal stroma can result in stromal haze and corneal fibrosis in patients undergoing keratorefractive therapy, modulation of TGFβ signaling through Hsp90 inhibition would represent a novel approach to prevent myofibroblast persistence.

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To facilitate social interactions, humans need to process the responses that other people make to their actions, including eye movements that could establish joint attention. Here, we investigated the neurophysiological correlates of the processing of observed gaze responses following the participants' own eye movement. These observed gaze responses could either establish, or fail to establish, joint attention.

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  • The London patient, who underwent stem-cell transplantation with CCR5-negative cells, maintained remission from HIV-1 for 30 months after stopping treatment, with undetectable viral loads in various body fluids.
  • Researchers used advanced testing methods to analyze blood, semen, cerebrospinal fluid, gut biopsies, and lymph nodes for HIV-1 presence and immune responses.
  • While the patient showed some very low positive signals for HIV-1 DNA in specific immune cells, the majority of tests returned negative results, suggesting a successful and sustained response to the treatment.
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Efficiently judging where someone else is looking is important for social interactions, allowing us a window into their mental state by establishing joint attention. Previous work has shown that judging the gaze direction of a non-foveally presented face is facilitated when the eyes of that face are directed towards the centre of the scene. This finding has been interpreted as an example of the human bias for misattributing observed ambiguous gaze signals as self-directed eye-contact.

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We tested whether gaze direction identification of individual faces can be modulated by prior social gaze encounters. In two experiments, participants first completed a joint-gaze learning task using a saccade/antisaccade paradigm. Participants would encounter some 'joint-gaze faces' that would consistently look at the participants saccade goal before participants looked there (Experiment 1) or would follow the participants gaze to the target (Experiment 2).

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  • The text refers to a correction made to a previously published article with the DOI: 10.1038/s42003-018-0226-0.
  • The correction is likely important for ensuring the accuracy and integrity of the research findings presented in the original article.
  • Readers are encouraged to check the corrected version for updated information that may affect the conclusions or interpretations of the study.
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  • A decade after the Berlin patient was reported as the only known case of HIV-1 cure, a new case demonstrates potential for HIV-1 remission through less severe treatment methods.
  • An adult HIV-1 patient successfully underwent allogeneic stem-cell transplantation from a CCR5Δ32/Δ32 donor for Hodgkin's lymphoma and maintained HIV-1 remission for 18 months post-treatment.
  • Current findings indicate that with this less toxic approach, similar outcomes to the Berlin patient may be achievable, although definitive conclusions about a cure remain uncertain.
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Dolutegravir (DTG), a second-generation integrase strand-transfer inhibitor (INSTI), is equivalent or superior to current non-nucleotide reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), and first-generation INSTI-based antiretroviral regimens (ARVs). It has the potential to make big improvements in HIV control globally and within patients. This is perhaps the most "precious" HIV drug available.

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  • Advances in next generation sequencing have made it easier to study genetics, but understanding genetic causes of eye diseases is still tough due to cost and limited access to human genetic data.
  • The International Mouse Phenotyping Consortium conducted a study evaluating 4,364 genes and found that 347 of them affect eye traits, with 75% being previously unknown in eye disease research.
  • This significant increase in known genes related to eye conditions could have future implications for understanding eye development and diseases in humans.
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