Post-translational modifications of transthyretin affect the triiodonine-binding potential.

Transthyretin (TTR) is a visceral protein, which facilitates the transport of thyroid hormones in blood and cerebrospinal fluid. The homotetrameric structure of TTR enables the simultaneous binding of two thyroid hormones per molecule. Each TTR subunit provides a single cysteine residue (Cys10 ), which is frequently affected by oxidative post-translational modifications.

Iodine status in Turkish populations and exposure to iodide uptake inhibitors.

Perchlorate, nitrate, and thiocyanate are competitive inhibitors of the sodium iodide symporter of the thyroid membrane. These inhibitors can decrease iodine uptake by the symporter into the thyroid gland and may disrupt thyroid function. This study assesses iodine status and exposure to iodide uptake inhibitors of non-pregnant and non-lactating adult women living in three different cities in Turkey (Istanbul, Isparta and Kayseri).

Mucopyocele of the maxillary sinus: a case report.

Mucoceles are defined as chronic, cystic lesions in the paranasal sinuses. When the mucocele content becomes infected, the lesion is defined as mucopyocele. Involvement of the maxillary sinus is rare.

Sublingual epidermoid cyst: a case report.

Epidermoid and dermoid cysts represent less than 0.01% of all oral cavity cysts. The cysts can be defined as epidermoid when the lining presents only epithelium, dermoid cysts when skin adnexa are found, and teratoid cysts when other tissue such as muscle, cartilage, and bone are present.

[Iatrogenic nasal meningocele: a cause of recurrent meningitis].

We present a 35-year-old male patient with an eight-year history of endoscopic nasal polypectomy followed by five episodes of meningitis (4 episodes in the past 3 years). His major complaints were right-sided nasal obstruction, frequent watery nasal discharge, headache, and fever. Physical examination revealed a mass in the right nasal cavity.

Non-Hodgkin's lymphoma of the nose and paranasal sinuses: a case report.

Primary non-Hodgkin lymphoma (NHL) of the nasal cavity is a rare neoplasm. They account for about 0.17-2% of all cases of NHL and 5.

Two novel mutations in the sixth transmembrane segment of the thyrotropin receptor gene causing hyperfunctioning thyroid nodules.

Autonomously functioning thyroid nodules (AFTNs) can present as hyperfunctioning adenomas or toxic multinodular goiters. In the last decade, a large number of activating mutations have been identified in the thyrotropin receptor (TSHR) gene in autonomously functioning thyroid nodules. Most have been situated close to, or within the sixth transmembrane segment and third intracellular loop of the TSHR where the receptor interacts with the Gs protein.

Endothelial function, insulin sensitivity and inflammatory markers in hyperprolactinemic pre-menopausal women.

Background: Hyperprolactinemia has been reported to be associated with abnormalities of carbohydrate metabolism. The aim of this study was to evaluate the effects of hyperprolactinemia and bromocriptine (Brc) treatment on endothelial function, insulin sensitivity and inflammatory markers in pre-menopausal women.

Methods: Sixteen hyperprolactinemic pre-menopausal women with pituitary adenomas were recruited and 20 healthy subjects were included as controls.