Sustainable and energy-saving hydrogen production binder-free and electrodeposited Ni-Mn-S nanowires on Ni-Cu 3-D substrates.

Electrochemical water splitting, with its oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), is undoubtedly the most eco-friendly and sustainable method to produce hydrogen. However, water splitting still requires improvement due to the high energy consumption caused by the slow kinetics and large thermodynamic potential requirements of OER. Urea-water electrolysis has become increasingly appealing compared to water-splitting because of the remarkable decline in the cell potential in the hydrogen production process and less energy consumption; it also offers a favorable opportunity to efficiently treat wastewater containing a significant amount of urea.

Hollow-like three-dimensional structure of methyl orange-delaminated TiC MXene nanocomposite for high-performance electrochemical sensing of tryptophan.

Tryptophan(Trp) is being explored as a potential biomarker for various diseases associated with decreased tryptophan levels; however, metabolomic methods are expensive and time-consuming and require extensive sample analysis, making them urgently needed for trace detection. To exploit the properties of TiC MXenes a rational porous methyl orange (MO)-delaminated TiC MXene was prepared via a facile mixing process for the electrocatalytic oxidation of Trp. The hollow-like 3D structure with a more open structure and the synergistic effect of MO and conductive TiC MXene enhanced its electrochemical catalytic capability toward Trp biosensing.

TiC MXene-based nanozyme as coreaction accelerator for enhancing electrochemiluminescence of glucose biosensing.

Delamination of the exfoliated multilayer MXenes with electro-catalysts, not only leads to increasing surface area for high electrochemiluminescent (ECL) signal tracer loading but also provides highly sensitive achievements in a coreaction accelerator manner. To this end, herein, we used bromophenol blue (BPB)-delaminated multilayer TiC MXene as both a coreaction accelerator to promote the electrochemiluminescent (ECL) reaction rate of luminol (LUM) and the co-reactant HO and a substrate for retaining high loading of glucose oxidase (GOx)-conjugated polyethylene imine (PEI) along with luminophore species into more open structure of TiC MXene for sensitive detection of glucose. In the presence of glucose, in situ generating HO product through a GOx-catalyzed process could produce abundant OH radicals via the peroxidase-like activity of the BPB@TiC in the LUM ECL reaction.

A label-free multicolor colorimetric and fluorescence dual mode biosensing of HIV-1 DNA based on the bifunctional NiFeO@UiO-66 nanozyme.

Finding the DNA of the human immune deficiency virus (HIV) with simple and sensitive detection is the main challenge in early diagnosis of AIDS. Herein, two-point separation strategies based on the colorimetric and fluorescence are introduced. The naked-eye qualitative and semiquantitative colorimetric, and also accuracy fluorescence quantification of HIV-1 DNA were applied using label-free NiFeO@UiO-66 nanozyme with both functions of peroxidase-mimetic like and emitting fluorescence.

Smartphone-Based Electrochemiluminescence for Visual Simultaneous Detection of and Tumor Suppressor Gene Methylation in Thyroid Cancer Patient Plasma.

Visual one-step simultaneous detection of low-abundance methylation is a crucial challenge in early cancer diagnosis in a simple manner. Through the design of a closed split bipolar electrochemistry system (BE), detection of promoter methylation of tumor suppressor genes in papillary thyroid cancer, and , was achieved using electrochemiluminescence. For this purpose, electrochemiluminescence of luminol loaded into the FeO@UiO-66 and gold nanorod-functionalized graphite-like carbon nitride nanosheet (AuNRs@CN NS), separately, on the anodic and cathodic pole bipolar electrodes (BPEs) in two different chambers of a bipolar cell were recorded on a smartphone camera.

Electrochemical immunosensor for determination of cardiac troponin I using two-dimensional metal-organic framework/FeO-COOH nanosheet composites loaded with thionine and pCTAB/DES modified electrode.

Cardiac troponin-I (CTnI) is one of the most popular biomarkers which can be utilized for the diagnosis and control of acute myocardial infarction in clinical practice. Here, a sandwich-type electrochemical immunosensor has been established using the zinc-based metal-organic framework/FeO-COOH/thionine labeled anti-CTnI monoclonal antibody (Ab-Zn-MOF/FeO-COOH/Thi) nanocomposite as signaling molecule and a polymer film of cetyltrimethylammonium bromide (pCTAB) in the presence of choline chloride-urea deep eutectic solvent (DES) and anti-CTnI polyclonal antibody (Ab) as immobilization substance of detecting surface. The porous ultrathin layers of Zn-MOF nanosheets successfully prepare a well-defined structure for FeO-COOH electrocatalyst and Thi within a certain two dimensional (2D) regions, which enhances electrochemical reduction of Thi.

Electrochemiluminescence paper-based screen-printed electrode for HbA1c detection using two-dimensional zirconium metal-organic framework/FeO nanosheet composites decorated with Au nanoclusters.

Glycated hemoglobin (HbA1c) is one of the most popular biomarkers which can be utilized for the diagnosis and control of diabetes in clinical practice. In this study, a sandwich paper-based electrochemiluminescence (ECL) biosensor has been developed using the zirconium metal-organic framework/FeO(trimethyl chitosan)/gold nanocluster (Zr-MOF/FeO(TMC)/AuNCs) nanocomposite as tracing tag to label anti-HbA1c monoclonal antibody and reduced graphene oxide (rGO) as immobilization platform of sensing element. The screen-printed electrodes (SPEs) were constructed and modified by sputtering a thick layer of gold on the paper substrate, followed by electrochemical reduction of aminophenylboronic acid (APBA)-functionalized GO to rGO/APBA, respectively.

Electrochemiluminescent biosensor for ultrasensitive detection of lymphoma at the early stage using CD20 markers as B cell-specific antigens.

Herein, by taking advantage of the special binding of an aptamer to the membrane surface of a B cell and accumulation of the positive charges of a nanocomposite, including luminol-chitosan-platinum nanoparticles (L-Cs-Pt NPs), on the negatively charge of the aptamer phosphate backbone, a sensitive, simple, selective and rapid strategy for the detection of lymphoma cells by a new label-free electrogenerated chemiluminescence (ECL) aptasensor has been introduced. With increasing concentrations of B lymphoma cells, the nanocomposite detaches from the aptamer, leading to a decrease in the ECL of a luminol and HO system. With high loading of luminol and Pt NPs on a chitosan, together with the electrocatalytic effect of Pt NPs, enhanced sensitive detection of cancer cells with a limit of detection of 31 cells/mL was achieved.

Point-of-care biosensors in medicine: a brief overview of our achievements in this field based on the conducted research in EMRI (endocrinology and metabolism research Institute of Tehran University of medical sciences) over the past fourteen years.

The growing demand of diagnostic tools with enhanced analytical characteristics in term of sensitivity, selectivity, and low response time has encouraged researches to conduct their research towards development of point-of-care (POC) biosensors. POC diagnostic devices are powerful tools for detection, diagnosis, and monitoring of diseases at its initial stage. The above characteristics encouraged us to conduct active multidisciplinary and collaborative research oriented towards the design and development of POC sensing systems.

Electrochemical sensors and biosensors based on the use of polyaniline and its nanocomposites: a review on recent advances.

Polyaniline and its composites with nanoparticles have been widely used in electrochemical sensor and biosensors due to their attractive properties and the option of tuning them by proper choice of materials. The review (with 191 references) describes the progress made in the recent years in polyaniline-based biosensors and their applications in clinical sensing, food quality control, and environmental monitoring. A first section summarizes the features of using polyaniline in biosensing systems.

Enhanced Visual Wireless Electrochemiluminescence Immunosensing of Prostate-Specific Antigen Based on the Luminol Loaded into MIL-53(Fe)-NH Accelerator and Hydrogen Evolution Reaction Mediation.

A sensitive prostate-specific antigen (PSA) detection method using a visual-readout closed bipolar electrode (BPE) system has been introduced by integration of hydrogen evolution reaction (HER) in cathodic pole and electrochemiluminescence (ECL) of luminol loaded within the MIL-53(Fe)-NH (L@MIL-53(Fe)-NH) in the anodic pole. The cathode of the BPE was electrochemically synthesized by 3D porous copper foam, followed by decorating with nitrogen-doped graphene nanosheet and ruthenium nanoparticles. As an alternative, we employed carboxylate-modified magnetic nanoparticles (MNPs) for immobilization of the primary antibody (Ab1) and utilized the L@MIL-53(Fe)-NH conjugated to secondary antibody (Ab2) as a signaling probe and coreaction accelerator.

Voltammetric immunosensor for E-cadherin promoter DNA methylation using a FeO-citric acid nanocomposite and a screen-printed carbon electrode modified with poly(vinyl alcohol) and reduced graphene oxide.

Silencing of tumor suppressor genes (E-cadherin) by promoter DNA methylation may lead to the development of invasive phenotypes in epithelial tissues. The authors describe an electrochemical nanobiosensor for early detection and screening of circulating methylated DNA as a biomarker for cancers. First, the antibody against 5-methylcytosine was physically immobilized onto modified with reduced graphene oxide and polyvinylalcohol.

Visual electrochemiluminescence biosensing of aflatoxin M1 based on luminol-functionalized, silver nanoparticle-decorated graphene oxide.

A sensitive electrochemiluminescence (ECL) aptasensor for aflatoxin M1 (AFM1) detection by a closed bipolar electrode (BPE) array has been introduced. The thiolated AFM1 aptamer was immobilized on gold nanoparticle-coated magnetic FeO nanoparticles (Apt-GMNPs). Luminol-functionalized silver nanoparticle-decorated graphene oxide (GO-L-AgNPs) participates in π-π interactions with the unpaired bases of the immobilized aptamer (Apt-GMNPs-GO-L-AgNPs).

Aptamer-conjugated Magnetic Nanoparticles as Targeted Magnetic Resonance Imaging Contrast Agent for Breast Cancer.

Early detection of breast cancer is the most effective way to improve the survival rate in women. Magnetic resonance imaging (MRI) offers high spatial resolution and good anatomic details, and its lower sensitivity can be improved by using targeted molecular imaging. In this study, AS1411 aptamer was conjugated to FeO@Au nanoparticles for specific targeting of mouse mammary carcinoma (4T1) cells that overexpress nucleolin.

Amplified detection of leukemia cancer cells using an aptamer-conjugated gold-coated magnetic nanoparticles on a nitrogen-doped graphene modified electrode.

The increasing demands for early, accurate and ultrasensitive diagnosis of cancers demonstrate the importance of the development of new amplification strategies or diagnostic technologies. In the present study, an aptamer-based electrochemical biosensor for ultrasensitive and selective detection of leukemia cancer cells has been introduced. The thiolated sgc8c aptamer was immobilized on gold nanoparticles-coated magnetic FeO nanoparticles (Apt-GMNPs).

Wireless electrochemiluminescence bipolar electrode array for visualized genotyping of single nucleotide polymorphism.

The development of simple, inexpensive, hand-held, user-friendly biosensor for high throughput and multiplexed genotyping of various single nucleotide polymorphisms (SNPs) in a single run experiment by a nonspecialist user is the main challenge in the analysis of DNA. Visualizing the signal and possibility to monitor SNPs by a digital camera opens a new horizon for the routine applications. In the present manuscript, a novel wireless electrochemiluminescence (ECL) DNA array is introduced for the visualized genotyping of different SNPs on the basis of ECL of luminol/hydrogen peroxide system on a bipolar electrode (BPE) array platform.

Dual amplification of single nucleotide polymorphism detection using graphene oxide and nanoporous gold electrode platform.

In the present manuscript, a strategy to prompt the sensitivity of a biosensor based on the dual amplification of signal by applying a nanoporous gold electrode (NPGE) as a support platform and soluble graphene oxide (GO) as an indicator has been developed. By increasing the surface area of the biosensing platform and because of unique GO/ss-DNA interactions, the sensitivity for the detection of SNPs is enhanced. In the presence of SNPs, because of less effective hybridization of mutant targets compared to complementary targets, further GO could adsorb on mutant targets-modified NPGE viaπ-π interactions, causing a large increase in the charge transfer resistance (Rct) of the electrode.

Carbon nanotube composite coated platinum electrode for detection of Ga(III).

This study demonstrates the application of composite multi-walled carbon nanotube (MWCNT) polyvinylchloride (MWNT-PVC) based on 7-(2-hydroxy-5-methoxybenzyl)-5,6,7,8,9,10-hexahydro-2H benzo [b][1,4,7,10,13] dioxa triaza cyclopentadecine-3,11(4H,12H)-dione ionophore for gallium sensor. The sensor shows a good Nernstian slope of 19.68 ± 0.