Publications by authors named "Seyram A Doe-Tetteh"
Article Synopsis
- * Recent studies have identified other mutations, like those in PIK3CA, which may also drive LCH independently from MAPK signaling, although their effects were not fully understood until now.
- * New research using a mouse model shows that PIK3CA mutations can contribute to LCH, and a patient's LCH with this mutation successfully responded to a targeted treatment (alpelisib), highlighting the potential for personalized therapies in treating histiocytic neoplasms.
Clin Cancer Res
July 2023
Article Synopsis
- A program was launched to provide free genomic testing for patients with rare cancers worldwide, specifically targeting histiocytosis, germ cell tumors (GCT), and pediatric cancers.
- Patients were recruited through social media and advocacy groups, and 333 were enrolled, with 288 providing tumor tissue for analysis, resulting in significant clinical benefits for patients receiving genomically guided therapy.
- The study highlighted the rarity of actionable genomic alterations in ovarian GCTs and demonstrated that direct outreach can effectively build cohorts for studying rare cancers' genomic landscapes.
