Motivation: Proteins accomplish cellular functions by interacting with each other, which makes the prediction of interaction sites a fundamental problem. As experimental methods are expensive and time consuming, computational prediction of the interaction sites has been studied extensively. Structure-based programs are the most accurate, while the sequence-based ones are much more widely applicable, as the sequences available outnumber the structures by two orders of magnitude.
View Article and Find Full Text PDFSeveral proteins work independently, but the majority work together to maintain the functions of the cell. Thus, it is crucial to know the interaction sites that facilitate protein-protein interactions. The development of effective computational methods is essential because experimental methods are expensive and time-consuming.
View Article and Find Full Text PDFCellular functions are governed by proteins, and, while some proteins work independently, most work by interacting with other proteins. As a result it is crucially important to know the interaction sites that facilitate the interactions between the proteins. Since the experimental methods are costly and time consuming, it is essential to develop effective computational methods.
View Article and Find Full Text PDFIn the wake of the COVID-19 pandemic, many firms lacked a strategy to cope with disruptions and maintain resiliency. In this study, we develop a measurement method to evaluate the impact of resilience strategies in a multi-stage supply chain (SC) in the presence of a pandemic. For the first time, we propose a method to deduce quantitative resilience assessment from simulation.
View Article and Find Full Text PDFIn the broad sense, the Bayesian networks (BN) are probabilistic graphical models that possess unique methodical features to model dependencies in complex networks, such as forward and backward propagation (inference) of disruptions. BNs have transitioned from an emerging topic to a growing research area in supply chain (SC) resilience and risk analysis. As a result, there is an acute need to review existing literature to ascertain recent developments and uncover future areas of research.
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