Publications by authors named "Seyedeh Sheila Seyed-Motahari"
Cancer Cell Int
September 2024
Article Synopsis
- * Allogeneic CAR-T cell therapies (allo-CAR-Ts) are being explored as an alternative to autologous therapies, showing promising results in early clinical trials, yet facing challenges like graft-versus-host disease (GvHD) and immune rejection.
- * The success of allo-CAR-Ts depends on factors such as the origin of the starter cells and gene editing techniques, and research is ongoing to address these challenges and maximize their potential for treating hematological malignancies.
Front Immunol
February 2023
Article Synopsis
- The immune system plays a crucial role in identifying and destroying tumor cells, but factors in the tumor microenvironment (TME) can weaken immune responses, making cancer treatment challenging.
- Cancer immunotherapy aims to enhance the immune system's ability to target tumors, with nanobodies (small antibody fragments from camels) showing promise due to their unique characteristics for improving immunotherapy effectiveness.
- Nanobodies facilitate T-cell and natural killer (NK) cell engagement with tumors and can be engineered to target cancer cells directly or block inhibitory signals, enhancing immune surveillance and reducing side effects in cancer treatment.
