Publications by authors named "Seyedeh Melika Ahmadi"
Correction: Enhanced clindamycin delivery using chitosan-coated niosomes to prevent Toxoplasma gondii strain VEG in pregnant mice: an experimental study.
Trop Med Health
October 2024
Article Synopsis
- Congenital toxoplasmosis in pregnant women is primarily caused by the first-time infection of Toxoplasma gondii, and treatments typically involve antibiotics like spiramycin and clindamycin, each with limitations in efficacy due to poor placental penetration.
- A study investigated the use of chitosan-coated niosomes (Cs-Nio) to enhance the delivery and effectiveness of clindamycin against the VEG strain of T. gondii in a pregnant mouse model.
- Results showed that Cs-Nio-Cli treatment significantly reduced T. gondii cysts in the brain and eyes, improved tissue health, and reduced inflammation and cell death, demonstrating a promising approach to treat congenital toxoplasmosis.
To overcome the challenges associated with the co-delivery of AuNPs (gold nanoparticles) and miRNA as an anti-breast cancer combination therapy, niosomal systems were developed using Span 60, cholesterol, and a cationic lipid (CTAB), and the formulations were optimized using Box-Behnken experimental design. The niosomal formulations with the smallest size were selected for further optimization of size, surface charge, entrapment efficiency, and stability. To achieve this, AuNPs and DSPE-PEG2000 (2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000)were added to the formulation.
View Article and Find Full Text PDFBreast cancer (BC) is considered one of the most frequent cancers among woman worldwide. While conventional therapy has been successful in treating many cases of breast cancer, drug resistance, heterogenicity, tumour features and recurrence, invasion, metastasis and the presence of breast cancer stem cells can hinder the effect of treatments, and can reduce the quality of life of patients. MicroRNAs (miRNAs) are short non-coding RNA molecules that play a crucial role in the development and progression of breast cancer.
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