Publications by authors named "Seyedeh Farzaneh Mahdavian"
Exosomes with Engineered Brain Derived Neurotrophic Factor on Their Surfaces Can Proliferate Menstrual Blood Derived Mesenchymal Stem Cells: Targeted Delivery for a Protein Drug.
Fatemeh Siamian Gorji Seyedeh Farzaneh Mahdavian Shabanali Khodashenas Zeinab Rezaee Kiasari Reza Valadan
Protein J
December 2024
Article Synopsis
- Engineering exosomes to display brain-derived neurotrophic factor (BDNF) on their surfaces can facilitate targeted drug delivery across the blood-brain barrier, enhancing therapeutic strategies in neuro-regenerative medicine.
- The BDNF gene was integrated into a lentiviral vector, and exosomes were produced by transducing HEK293T cells, with successful surface expression confirmed through various characterization methods, including Western blot and ELISA.
- Treatment with these engineered exosomes significantly increased the proliferation of menstrual blood-derived mesenchymal stem cells (Mens-MSCs) and elevated the expression of key genes (bcl2 and nestin), indicating retained biological activity of BDNF.