Publications by authors named "Seyedahmad Seyedalinaghi"

Article Synopsis
  • Hepatitis B virus (HBV) infection is a significant public health issue among people who inject drugs (PWID), highlighting the importance of testing and vaccination to reduce infection rates and chronic health issues.
  • A study of 2,684 PWID in Iran revealed that only 14.2% reported having been tested for HBV, while 16.4% had been vaccinated, with factors such as academic education and a history of homelessness influencing these rates.
  • The findings indicate a crucial need to identify and overcome barriers preventing PWID from accessing HBV testing and vaccination to alleviate the impact of HBV within this vulnerable demographic.
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 Olfactory dysfunction (OD) has emerged as a notable symptom among coronavirus disease 2019 (COVID-19) patients, with its prevalence varying among different populations. Recognizing the need to provide therapeutic solutions for these individuals, the present study seeks to comprehensively review the current evidence on potential underlying mechanisms and treatment modalities to manage OD in COVID-19 patients.  To review the recent evidence on treatments for OD in COVID-19.

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Introduction: The prevalence of telehealth has witnessed a significant increase in various medical domains, especially in endocrinology. Telehealth brings about considerable advantages for both patients and health care professionals. However, despite these positive aspects, the growing prominence of telehealth is accompanied by certain challenges.

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Introduction: In January 2020, WHO declared the 2019 Coronavirus Disease (COVID-19) a pandemic. Though COVID-19 vaccines are recommended, ongoing surveillance is crucial due to potential unforeseen events. Evaluation of long-term effectiveness and safety and addressing emerging variants are vital.

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Article Synopsis
  • The study investigates the prevalence of COVID-19 among prisoners, highlighting the increased risk due to confined spaces and close contact in prisons.
  • It analyzed English-language studies published from 2019 to July 2023, using various databases and statistical methods to determine prevalence rates, finding a pooled prevalence of around 20% to 25%.
  • The study suggests that by implementing better planning in prison environments, the spread of COVID-19 among inmates could be significantly reduced.
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Introduction: This study examines the efficacy and safety of three COVID-19 booster vaccines including mRNA-based vaccines (BNT162b2 (BioNTech/Pfizer) and/or mRNA-1273 (Moderna)), Non-Replicating Viral-Vector vaccines (ChAdOx1 nCoV-19 vaccine (AstraZeneca) and/or Ad26. COV2.S (Johnson & Johnson)), and Protein Subunit vaccine (SpikoGen) in immunosuppressed patients.

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Objectives: Emerging publications indicate that diabetes predisposes patients with COVID-19 to more severe complications, which is partly attributed to inflammatory condition. In the current review, we reviewed recent published literature to provide evidence on the role of insulin resistance (IR) in diabetes, the association between diabetes and COVID-19 severity and mortality, the impact of COVID-19 infection on incident new-onset diabetes, mechanisms responsible for IR in COVID-19 patients, and the predictive value of different surrogates of IR in COVID-19.

Method: The literature search performs to find out studies that have assessed the association between IR surrogates and morbidity and mortality in patients with COVID-19.

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Article Synopsis
  • The systematic review and meta-analysis aimed to analyze and compare the effectiveness of adrenalectomy versus conservative treatment for patients with mild autonomous cortisol secretion (MACS), a common adrenal condition that can lead to several health issues without the classic symptoms of Cushing's syndrome.
  • The study included data from fifteen articles involving 933 patients, and found that adrenalectomy showed overall benefits in managing comorbidities related to MACS, particularly in reducing high blood pressure and improving bone mineral density.
  • Subgroup analysis highlighted significant advantages of adrenalectomy in lowering systolic and diastolic blood pressure, and improving bone health, while no major differences were found in other health outcomes between the two treatment options.*
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Objective: To assess the risk of developing pulmonary tuberculosis (TB) in accordance with prior history of COVID-19 infection.

Background: Since the advent of the COVID-19 pandemic much discussion has been had on the possible role it might play on global efforts to combat TB; most, focusing on the pandemic's impact on health care systems' capabilities to manage TB cases. Mechanisms have also been proposed by which the COVID-19 infection may directly affect individuals' chance of developing TB infection.

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Introduction: People living with HIV (PLWH) are more susceptible to acquiring and having serious consequences from COVID-19. The objective of this study was to examine the correlation between COVID-19 infection and other risk factors in these patients.

Methods: This is a descriptive-analytical study recruiting 160 PLWH referred to the Behavioral Disease Counselling Centre of Imam Khomeini Hospital in Tehran in 2021.

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Article Synopsis
  • Tuberculosis (TB) remains a significant global health issue, necessitating timely diagnosis and treatment; however, anti-TB drugs can cause hepatotoxicity, risking treatment continuation.
  • This study examined patients who experienced hepatotoxicity from anti-TB drugs, identifying female gender, weight loss, heart disease, and high liver enzyme levels as risk factors for unsuccessful retreatment.
  • Two strategies for managing hepatotoxicity involved starting treatment at full or minimum doses, with no significant differences in outcomes, highlighting the need to better understand and address drug-induced liver damage in TB therapy.
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Objective: () is a cyanobacterium proven to have anti-inflammatory, antiviral, and antioxidant effects. However, the effect of high-dose supplementation on hospitalized adults with COVID-19 is currently unclear. This study aimed to evaluate the efficacy and safety of high-dose for SARS-CoV-2 infection.

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Purpose: In the present study, biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) containing insulin were loaded in sodium alginate/jeffamine (ALG/jeff) hydrogel for prolonged delivery of insulin. The main aim of this work was to fabricate an efficient insulin delivery system to improve patient adherence by decreasing the repetition of injections.

Methods: Swelling and morphological properties and crosslinking efficiency of ALG/jeff hydrogel were assessed.

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Article Synopsis
  • SARS-CoV-2, the virus behind COVID-19, has evolved into several variants since its emergence in late 2019, including the notable Omicron and Delta variants.
  • A systematic review assessed the differences between these variants by analyzing 58 articles and over 10,000 pieces of evidence.
  • Findings indicate that Omicron is linked to lower hospitalization and severity rates compared to Delta, highlighting the need for ongoing monitoring and updated vaccination strategies.
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Introduction: COVID-19 caused by SARS-CoV-2, commonly presents with symptoms such as fever and shortness of breath but can also affect other organs. There is growing evidence pointing to potential eye complications. In this article, we aim to systematically review the ocular manifestations of COVID-19.

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Article Synopsis
  • - The COVID-19 pandemic has resulted in significant underreporting of cases due to a large number of asymptomatic infections, making it crucial to accurately estimate the true number of infections for effective treatment and prevention strategies.
  • - A systematic review of seven studies from various regions used respondent-driven sampling (RDS) methods to analyze COVID-19 prevalence, revealing that actual infection rates were often two to fifty times higher than reported cases, with specific rates found at 2.6% in Sierra Leone and 2.4% in Austria.
  • - The findings highlight the effectiveness and cost-efficiency of RDS in identifying hidden populations of COVID-19, suggesting that this approach could be useful for future epidemics to better assess and respond to
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Background And Aims: A healthy diet play an important role in the prevention and even treatment of various diseases. Proper nutrition plays an important role in boosting of immune system. These include the consumption of macronutrients such as proteins, lipids, carbohydrates, and also micronutrients including vitamins.

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Objective: This article aimed to analyze upper endoscopic findings in the HIV patient population to elucidate the upper-gastrointestinal complications related to HIV infection. Gastrointestinal (GI) disorders in individuals living with HIV/AIDS exhibit diverse and often nonspecific manifestations, imposing substantial morbidity and mortality burdens. Endoscopic evaluation with biopsies is essential in the diagnosis and management of these conditions.

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Article Synopsis
  • * A systematic review of 23 cross-sectional studies involving over 16,315 truck drivers revealed a high seroprevalence of HIV, particularly noting a staggering 56% prevalence rate in South Africa.
  • * Key risk factors identified include low awareness of HIV/AIDS, limited condom use, and lifestyle factors like time away from home, socio-economic status, drug/alcohol use, and sexual practices, suggesting that targeted interventions are essential for prevention.
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Introduction: Severe COVID-19 management is still challenging. Having a laboratory factor to predict the severity of a patient's condition can be very useful in how to approach each patient. There have been studies concentrating on the correlation between serum C-reactive protein (CRP) level and COVID-19 severity but we aim to reach a threshold for CRP in disease severity determination.

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