The role of microRNAs in the development, progression and drug resistance of chronic myeloid leukemia and their potential clinical significance.

Chronic myeloid leukemia (CML) is a cancer of the bone marrow characterized by an uncontrolled increase in the production of myeloid cells. MicroRNAs (miRNAs) are a group of non-coding RNA molecules with a length of 19 to 25 nucleotides that participate in the regulation of gene expression after transcription. They also play an important role in many physiological processes, such as proliferation, differentiation, apoptosis, and hematopoiesis.