Cu-metal organic frameworks (Cu-MOF) as an environment-friendly and economical catalyst for one pot synthesis of tacrine derivatives.

The present work describes the catalytic activity of Cu-MOF for the one-pot synthesis of tacrine derivatives a four-component reaction of 2-hydroxynaphthalene-1,4-dione, aldehydes, malononitrile and cycloketones in the presence of AlCl. The structure of the synthesized compound is confirmed by H NMR, C NMR, IR, and MASS. The catalyst prepared under pressure is characterized by powder X-ray diffraction and SEM.