The effect of enoxaparin and clopidogrel on survival of random skin flap in rat animal model.

Background: Necrosis of skin flaps is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival.

Methods: Forty male, adult Sprague-Dawlay rats were divided randomly into 4 groups.