OSCE as a tool for evaluation of practical semiology in comparison to MCQ & oral examination.

Objective: To compare medical students' perceptions regarding Objectively Structured Clinical Examination (OSCE) with Multiple Choice Questions (MCQ) and Oral exam in their semiology course.

Methods: We used a questionnaire with 10 questions regarding the quality of exam (Likert scale) and 3 questions regarding the difficulty, being educative and with descriptive scales. The study carried out in the Centre for Clinical skills located at Firozgar Teaching Hospital affiliated to Iran University of Medical Science.

Structural model of the OPA1 GTPase domain may explain the molecular consequences of a novel mutation in a family with autosomal dominant optic atrophy.

Autosomal dominant optic atrophy (ADOA) is the most frequent hereditary optic neuropathy. Three loci have been reported for ADOA: a major locus, harboring all identified mutations to date, maps to 3q28 (OPA1), a second locus is linked to 18q12.2-q12.