The efficacy of itraconazole, fluticasone and doxycycline in chronic rhinosinusitis.

Background: Different treatment strategies for chronic rhinosinusitis (CRS) have been evaluated. Here we aimed to investigate the effects of fluticasone spray alone and in combination with itraconazole or doxycycline.

Methods: This is an open-label clinical trial performed in 2020-2021 in Isfahan on patients with CRS.