Deficient Expression of in Human Testis is Related to Spermatogenesis Dysfunction, Especially in Meiosis I.

Introduction: () contributes to miRNA biogenesis, and defects in its expression could lead to defects in spermatogenesis.

Methods: Here, we assess gene and protein expression levels of in the testicular biopsy specimens obtained from men with obstructive azoospermia (OA, n = 19) and various types of non-obstructive azoospermia (NOA) including maturation arrest (MA, n = 17), Sertoli cell-only syndrome (SCOS, n = 20) and hypospermatogenesis (HYPO, 18). Also, samples of men with NOA were divided into two groups based on successful and unsuccessful sperm recovery, NOA+ in 21 patients and NOA- in 34 patients.