Rip It off: Nitro to Nitroso Reduction by Iron Half-Sandwich Complexes.

Activation of [FeCl(dppe)Cp] () by chloride abstraction with Na[BAr] (X = F, [B(3,5-(CF)-CH)]; X = Cl, [B(3,5-Cl-CH)]) permits reactions with a range of nitro aromatics, RCHNO (R = halogen, Me, OMe, NO or NMe), to give the cationic iron nitroso complexes [Fe{N(O)-CHR}(dppe)Cp][BAr]) ([][BAr]). Similar reactions of and Na[BAr] with [Fe(NCCHNO)(dppe)Cp][BAr] gave bimetallic [{Fe(dppe)Cp}{μ-N≡CCHN(O)}][BAr]. However, reactions of and Na[BAr] with 4-nitrophenol gave the first example of the bench-stable iron half-sandwich phenolate complex [Fe(OCHNO)(dppe)Cp] rather than NO activation.

Deciphering inhibitory activity of flavonoids against tau protein kinases: a coupled molecular docking and quantum chemical study.

Today, Alzheimer's disease (AD) is one of the most important neurodegenerative disorders that affected millions of people worldwide. Hundreds of academic investigations highlighted the potential roles of natural metabolites in the cornerstone of AD prevention. Nevertheless, alkaloids are only metabolites that successfully showed promising clinical therapeutic effects on the prevention of AD.

Synthesis, characterization, anti-diabetic potential and DFT studies of 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde oxime.

A new compound named 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde oxime (7-Oxime) was synthesized and characterized by FT-IR, FT-Raman, H NMR and C NMR techniques. The conformer possibilities were studied to find the most stable conformer and its molecular geometry. Then, the dimer form of the most stable monomer was built and optimized.

Differential α-amylase/α-glucosidase inhibitory activities of plant-derived phenolic compounds: a virtual screening perspective for the treatment of obesity and diabetes.

Recently, due to their biological properties, polyphenol-rich functional foods have been proposed to be unique supplementary and nutraceutical treatments for diabetes mellitus. Inhibition of α-amylase and α-glucosidase enzymes using natural products (especially polyphenols) is a novel oral policy to regulate carbohydrate metabolism and hyperglycemia. The present study aims to evaluate the α-amylase and α-glucosidase inhibitory activity of 26 polyphenols using molecular docking and virtual screening studies.