Evaluation of biocompatibility and osseointegration of multi-component TiAl6V4 titanium alloy implants.

This study aimed to investigate the biocompatibility and osseointegration of novel titanium (Ti) implants with a perforated part with high surface roughness (Ra >4 μm) and a smooth solid part (test group), as compared to smooth solid Ti implants (control group; Ra < 0.8 μm). Test and control implants were implanted in rabbit femurs.

Evaluation of hMSCs Response to Sodium Alginate / Bioactive Glass Composite Paste: Effect of CaO/PO, Sodium Alginate Concentration and P/L Ratios.

Background: Bioactive glasses with different compositions have been extensively used as bone tissue engineering. Preparation, development and characterization of alginate pastes containing bioglass for bone repair applications were the purposes of this study.

Objective: The injectable bone pastes were produced from sol-gel derived bioactive glass nanoparticles with various CaO/PO ratios of 19, 9.

Reline-assisted green and facile synthesis of fluorapatite nanoparticles.

A fast, simple and sustainable method based on choline chloride-urea deep eutectic solvent (known as Reline) was employed to synthesize nanosized fluorapatite (FA) particles. Using XRD, FESEM, TEM, EDS, and FTIR, the formation of FA nanoparticles with average crystal size of ~34nm, percent crystallinity of 93%, particle size of ~45nm, and high crystal, elemental, and structural purity was confirmed. The MTT cytotoxicity assay endorsed the non-toxicity of as-synthesized FA nanoparticles.

Revival of pure titanium for dynamically loaded porous implants using additive manufacturing.

Additive manufacturing techniques are getting more and more established as reliable methods for producing porous metal implants thanks to the almost full geometrical and mechanical control of the designed porous biomaterial. Today, Ti6Al4V ELI is still the most widely used material for porous implants, and none or little interest goes to pure titanium for use in orthopedic or load-bearing implants. Given the special mechanical behavior of cellular structures and the material properties inherent to the additive manufacturing of metals, the aim of this study is to investigate the properties of selective laser melted pure unalloyed titanium porous structures.

Additively Manufactured Open-Cell Porous Biomaterials Made from Six Different Space-Filling Unit Cells: The Mechanical and Morphological Properties.

It is known that the mechanical properties of bone-mimicking porous biomaterials are a function of the morphological properties of the porous structure, including the configuration and size of the repeating unit cell from which they are made. However, the literature on this topic is limited, primarily because of the challenge in fabricating porous biomaterials with arbitrarily complex morphological designs. In the present work, we studied the relationship between relative density (RD) of porous Ti6Al4V EFI alloy and five compressive properties of the material, namely elastic gradient or modulus (E), first maximum stress, plateau stress, yield stress, and energy absorption.