MIL-88B(Fe)-reduced graphene oxide as an artificial enzyme for gold nanorod etching and its application to develop the prostate-specific antigen immunosensor.

An immunosensor based on gold nanorods (AuNRs) etchant activity of a metal-organic framework (MOF): MIL-88B(Fe)-reduced graphene oxide (rGMOF) was developed for the determination of prostate-specific antigen (PSA). Several techniques, including FTIR, UV-Vis spectrophotometry, XRD, and electron microscopy, were employed to characterize the MOFs containing iron-oxygen clusters on the surface of reduced graphene oxide. Enzyme mimetic activity of rGMOF before and after bioconjugation with antibodies was calculated as 8.

Designing a magnetic inductive micro-electrode for virus monitoring: modelling and feasibility for hepatitis B virus.

A simple model is designed for an inductive immunosensor in which the magnetic particles are attached to the bioreceptors to form a sandwich on the surface of an inductor. The inductor consists of a coil covered on a silicon oxide wafer. The coil comprises 250 turns of a planar gold wire, which is approximately 200 nm thick and 392 mm long, placed in a circle with a diameter of 2 mm.

Ultrasensitive interdigitated capacitance immunosensor using gold nanoparticles.

Immunosensors based on interdigitated electrodes (IDEs), have recently demonstrated significant improvements in the sensitivity of capacitance detection. Herein, a novel type of highly sensitive, compact and portable immunosensor based on a gold interdigital capacitor has been designed and developed for the rapid detection of hepatitis B surface antigen (HBsAg). To improve the efficiency of antibody immobilization and time-saving, a self-assembled monolayer (SAM) of 2-mercaptoethylamine film was coated on IDEs.

Magnetic nanoparticle-based immunosensor for electrochemical detection of hepatitis B surface antigen.

An electrochemical immunosensor was developed for the detection of hepatitis B surface antigen (HBsAg). The biotinylated hepatitis B surface antibody was immobilized on streptavidin magnetic nanoparticles and used for targeting the HBsAg. By the addition of horseradish peroxidase conjugated with secondary antibody (HRP-HBsAb), a sandwich-type immunoassay format was formed.