Prospective Acid Reflux Study of Iran (PARSI): methodology and study design.

Background: Gastroesophageal reflux disease is a common and chronic disorder but long term, prospective studies of the fate of patients seeking medical advice are scarce. This is especially prominent when looking at non-erosive reflux disease (NERD) patients.

Methods: We designed a prospective cohort to assess the long term outcome of GERD patients referring to gastroenterologists.