Publications by authors named "Seyed Mahbod Baharnoori"
Drug delivery to the ocular system is affected by anatomical factors like the corneal epithelium, blinking reflex, aqueous blood barrier, and retinal blood barrier, which lead to quick removal from the site and inefficient drug delivery. Developing a drug delivery mechanism that targets specific eye tissue is a major hurdle for researchers. Our study examines the challenges of drug absorption in these pathways.
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- Infectious keratitis in children under two years old can cause severe issues like vision loss and blindness, but data on this age group is limited, prompting a study to examine its causes and treatment.
- The study reviewed 57 cases from July 2005 to December 2022, revealing that most affected children had predisposing factors such as prior eye trauma or surgery, with Pseudomonas aeruginosa being the most common pathogen.
- Findings showed that while medical treatments were effective against infections, many children still required surgical intervention, indicating a need for improved management strategies in this vulnerable population.
The skin is subject to damage from the surrounding environment. The repair of skin wounds can be very challenging due to several factors such as severe injuries, concomitant infections, or comorbidities such as diabetes. Different drugs and wound dressings have been used to treat skin wounds.
View Article and Find Full Text PDFAll about traumatic cataracts: narrative review.
J Cataract Refract Surg
July 2024
Ocular trauma is an important cause of monocular blindness worldwide. Injury to the lens after blunt or penetrating trauma is common and can result in vision impairment. Selecting the most appropriate therapeutic approaches depends on factors such as patients' age, mechanism of trauma, and underlying clinical conditions.
View Article and Find Full Text PDFMesenchymal stem/stromal cells (MSCs) are considered a valuable option to treat ocular surface disorders such as mustard keratopathy (MK). MK often leads to vision impairment due to corneal opacification and neovascularization and cellular senescence seems to have a role in its pathophysiology. Herein, we utilized intrastromal MSC injections to treat MK.
View Article and Find Full Text PDFPurpose: Different approaches to delivery of mesenchymal stem/stromal cells (MSCs) for ameliorating corneal injuries have been investigated. This study was aimed to compare the efficacy of intrastromal and subconjunctival injection of human bone marrow-derived MSCs (hBM-MSCs) in a corneal epithelial injury model.
Methods: Twenty-four C57BL/6J mice underwent total corneal and limbal epithelial debridement.
Purpose: To present the 7-year experience of a tertiary eye hospital while exploring possible risk factors and incidence of infectious keratitis in patients undergoing standard corneal cross-linking (CXL).
Methods: This retrospective cohort study included patients with progressive keratoconus undergoing standard CXL in the Farabi Eye Hospital and all other patients who had undergone CXL in other facilities and were diagnosed as having infectious keratitis in the 7-year period of the study.
Results: Among the total of 4,863 eyes that underwent CXL, 6 eyes developed infectious keratitis, yielding an incidence rate of 0.
Article Synopsis
- Corneal diseases are a major cause of blindness globally, often requiring replacement procedures like corneal allograft or keratoplasty, which not everyone can access due to donor shortages.
- There is a growing interest in synthetic implants, such as artificial corneas, which could provide a viable alternative for those unable to receive traditional transplants.
- The review highlights various treatment options for corneal issues, explores current biomaterials for regeneration, and discusses the potential of nanotechnology in enhancing the development of better corneal implants.
Mustard agents are vesicants that were used in warfare multiple times. They are potent alkylating agents that activate cellular pathways of apoptosis, increase oxidative stress, and induce inflammation. Eyes are particularly susceptible to mustard exposure with a wide range of ocular surface damage.
View Article and Find Full Text PDFAllogeneic hematopoietic stem cell transplantation is a definitive therapy for a variety of disorders. One of the complications is acute graft-versus-host disease (aGVHD), which has a high mortality rate. Patients can also develop chronic graft-versus-host disease (cGVHD), a more indolent yet afflicting condition that affects up to 70% of patients.
View Article and Find Full Text PDFThe corneal epithelium is composed of nonkeratinized stratified squamous cells and has a significant turnover rate. Limbal integrity is vital to maintain the clarity and avascularity of the cornea as well as regeneration of the corneal epithelium. Limbal epithelial stem cells (LESCs) are located in the basal epithelial layer of the limbus and preserve this homeostasis.
View Article and Find Full Text PDFPurpose: To determine orbital anatomical parameters that affect surgical outcome of deep lateral orbital wall decompression.
Methods: Twenty orbits of 20 patients with moderate proptosis (maximum 25 mm) due to thyroid eye disease who were stable for at least 6 months were included in this prospective cohort study. Four parameters including lateral orbital wall distance (LOWD), removable surface area (RSA), removable surface length (RSL), and sphenoid door jamb thickness (SDJ) were evaluated by computed tomography (CT) scan prior to surgery in these patients.