Technetium-99m Tricarbonyl Labeled a Broad-spectrum Quinolone as a Specific Imaging Agent in Infection Diseases.

Nuclear medicine imaging has been used to localize infection sites, and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [Tc (CO) (HO)] core in order to evaluate its feasibility as an infection imaging agent for use. The stability of radioconjugate was checked in human serum at 37 °C and biodistribution was studied in mice.