A rare cytogenetic presentation of acute myeloid leukemia (AML-M2).

Acute myeloid leukemia (AML) with t(8;21)(q22;q22) generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t(8;21) category (WHO)/AML-M2 (FAB), generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult cases of this category with unusual karyotype.

Rare and recurrent chromosomal abnormalities and their clinical relevance in pediatric acute leukemia of south Indian population.

Background And Objectives: This cytogenetic study detects a wide variety of common, rare and novel chromosomal abnormalities in patients with hematological disorders, providing valuable diagnostic and prognostic information.

Materials And Methods: We addressed the utility of the cytogenetic technique in 50 patients of pediatric acute leukemia prospectively.

Results: Successful cultures were found in 44 patients (88%) and abnormal karyotypes in 22 (44%).

Combined study of cytogenetics and fluorescence in situ hybridization (FISH) analysis in childhood acute lymphoblastic leukemia (ALL) in a tertiary cancer centre in South India.

FISH is one of the most sensitive molecular methods to detect genetic abnormalities with DNA probes. When cytogenetic studies are normal or insufficient, FISH may detect cryptic rearrangements, rare or slowly proliferative abnormal populations in non-mitotic cells. We cytogenetically evaluated 70 childhood ALL - 67.