Concurrent Hepatotoxicity and Neutropenia Induced by Clozapine.

Clozapine is known as one of the atypical antipsychotics which is placed in the second line of medical treatment for schizophrenia due to its hematologic complications. It is used in cases of resistance to treatment. Some side effects of clozapine include leukopenia, granulocytopenia, fever, hepatotoxicity, sedation, dizziness, hypotension, weight gain, constipation, and seizure.

Cloning and Expression of Gene in as a Food Grade Vaccine.

Background: Brucellosis is still an important health problem in under developing countries and researches for finding efficient vaccine are going on. gene is a good candidate for brucellosis vaccine and investigations showed that ( with several positive characteristic are attractive for protein expression as a live delivery vectors. These fast growing bacteria need no aeration, are easy to handle, have no exotoxin, endotoxin and protease, so the cost of culturing is inexpensive.

Alterations in oxidative stress markers and its correlation with clinical findings in schizophrenic patients consuming perphenazine, clozapine and risperidone.

Background And Objective: Today, the role of oxidative stress in development of schizophrenia has gained attention. Also, some atypical antipsychotic agents showed antioxidant properties. Therefore, in this study, we evaluated the level of oxidative stress parameters between patients treated with perphenazine, clozapine and risperidone and their relationship with schizophrenia symptoms' severity.

Disease-Related Variables and Depression Among Iranian Patients with Parkinson Disease.

Background: The factors affecting the correlation between Parkinson disease (PD) and depression have remained unclear.

Objectives: We assessed the prevalence of depression among patients with PD and the association between PD-related variables and depression severity.

Patients And Methods: This is a cross-sectional study performed in Kermanshah Province of Iran.

Comparison of the genetic convergence between mycobacterium strains by three RFLP-based methods in central province of Iran.

Objectives: The utilization of molecular techniques in the epidemiology of tuberculosis have provided an opportunity for using effective markers to trace the transmission of the disease. The purpose of this study was to compare the genetic patterns of Mycobacterium tuberculosis by three methods of RFLP technique.

Materials And Methods: In a cross-sectional and prospective study, 95 strains of M.

Drug resistance pattern and associated risk factors of tuberculosis patients in the central province of Iran.

Background: One of the fundamental issues of infectious disease treatment is drug resistance. The aim of the present study was to investigate the first-line anti-tuberculosis drug resistance rates and determine the risk factors related to multidrug resistant mycobacterium tuberculosis.

Methods: From March 2011 to September 2012, mycobacterial strains were collected from one hundred fifteen diagnosed smear positive patients in the central province of Iran and tested for drug susceptible against ethambutol, rifampicin, isoniazid and streptomycin and the risk factors influencing the development of drug resistance were determined.