Publications by authors named "Seyed Amir Sadeghi"
Article Synopsis
- - The study identifies the TRIM25 gene's role in COVID-19, revealing that lower expression levels of this gene are linked to more severe disease outcomes compared to milder cases and healthy individuals.
- - The research involved analyzing blood samples from 330 COVID-19 patients and 160 healthy individuals, using quantitative Real-time PCR to assess TRIM25 expression and its correlation with disease severity.
- - Results indicate that increased TRIM25 expression can reduce SARS-CoV-2 virus replication and promote immune response by inducing beta-interferon, highlighting its potential as a therapeutic target for COVID-19 treatment.
Article Synopsis
- Heat shock proteins (HSPs) can boost immune responses, and this study specifically evaluates fragments of Hsp70 and Hsp27 as vaccine adjuvants to enhance immunity against HIV-1 Nef.
- Researchers created nanoparticles to deliver DNA constructs encoding these HSPs fused with Nef, and assessed their effectiveness in both lab cultures and live mice.
- Results showed that the C-Hsp70 fragment was particularly effective in promoting strong immune responses, including higher antibody and cytokine production, making it a promising candidate for improving HIV-1 vaccines.
Article Synopsis
- * Researchers created DNA constructs for HIV-1 Nef, IFNγ, and CD40L, and tested them on groups of female BALB/c mice to assess immune responses over time.
- * Results showed that fusion DNA constructs of IFNγ-Nef and CD40L-Nef significantly activated immune responses, suggesting these constructs could be promising options for developing an effective HIV-1 vaccine.
Objective: The innate immune response in humans involves a wide variety of factors, including the tripartite motif-containing 5α (TRIM5α) and 22 (TRIM22) as a cluster of genes on chromosome 11 that have exhibited antiviral activity in several viral infections. We analyzed the correlation of the expression of TRIM5α and TRIM22 with the severity of Coronavirus Disease 2019 (COVID-19) in blood samples of 330 patients, divided into two groups of severe and mild disease, versus the healthy individuals who never had contact with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Methods: The transcription level of TRIM5α and TRIM22 was determined by quantitative real-time polymerase chain reaction (qPCR).
Objective: Most patients infected with the novel coronavirus (SARS-CoV-2), as the causative agent of COVID-19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID-19 patients and to investigate the correlation between serum inflammatory cytokines and the disease severity.
Methods: In this prospective cross-sectional study, 50 patients with COVID-19 and 20 patients without COVID-19 were enrolled.