Publications by authors named "Seyda Yildiz Arslan"
Article Synopsis
- The study explores how iron oxide-based magnetic nanoparticles (MNPs) interact with cells through protein secretion and employs machine learning-assisted SERS for analysis.
- The researchers developed various MNPs with different surface modifications, significantly impacting their size, shape, and charge, which were assessed using techniques like transmission electron microscopy (TEM).
- Results showed that smaller MNPs adhered better to cells, and those encapsulated with polyethylenimine (PEI) enhanced the secretion of the recombinant azurin protein, highlighting the important role of MNP properties in cell interactions and potential applications in protein delivery.
Article Synopsis
- This study introduces a new breast cancer treatment that uses magnetic fields to heat nanoparticles for gene delivery and expression.
- The researchers developed nanoparticles that can carry a gene encoding an anti-cancer protein while generating heat when exposed to an alternating current magnetic field.
- Results showed that this method effectively increased cancer cell death while sparing non-cancerous cells, indicating a potential breakthrough in targeted cancer therapies.
Unlabelled: (previously described as ) is a yeast that produces high-level heterologous proteins with a wide range of applications in medicine and industry. The methanol-induced alcohol oxidase I promoter (P) is frequently used for protein expression in this yeast. However, limitations on the use of methanol have been observed in large-scale production, including its flammability, toxicity, and need for special handling.
View Article and Find Full Text PDFTransfection efficiency of the immortalized human breast epithelial cell line MCF-10A remains an issue that needs to be resolved. In this study, it was aimed to deliver a recombinant DNA (pCMV-Azu-GFP) to the MCF-10A cells by the magnetofection method using magnetic nanoparticles (MNPs) and a simple magnet to accelerate the DNA delivery. Surface positively modified silica-coated iron oxide MNPs (MSNP-NH) were produced and characterized via TEM, FTIR, and DLS analyses.
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