Publications by authors named "Seyda Karabulut"
Purpose: Duchenne muscular dystrophy (DMD) is a severe, progressive condition characterized by muscle degeneration and weakness, significantly affecting respiratory function. This study aimed to evaluate the presence of sleep-disordered breathing (SDB) in children with DMD and investigate the relationships between sleep and respiratory function using spirometry, sniff nasal inspiratory pressure (SNIP), and polysomnography (PSG) along with capnography.
Research Question: Can low SNIP be a guide for detecting respiratory muscle involvement early and determining the right time to perform early PSG and capnography in DMD?
Study Design: Prospective, observational, cross-sectional study.
Background: Our study aimed to identify the social domains that pose the greatest barriers to managing and supporting pwCF, particularly in relation to income levels.
Methods: To identify associations between income and health outcomes in pwCF in our center the shorter form of the survey "Your Current Life Situation" (YCLS) was used in face-to-face interviews. Participants were also asked to complete the validated Turkish versions of the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder scale (GAD-7) to assess depression and anxiety, respectively.
Objective: Central sleep apnea (CSA) is a rare condition in children; however, it can cause significant morbidity if not diagnosed early. We aimed to increase the knowledge about CSA in children by describing the clinical characteristics of children diagnosed with CSA at our sleep center.
Material And Methods: We retrospectively reviewed 1263 polysomnographies (PSG) performed between 2012 and 2023 at our tertiary sleep center and evaluated the clinical characteristics of the patients with CSA.
Introduction: Pulmonary exacerbations increase the requirement of aminoglycoside (AG) antibiotics in people with cystic fibrosis (pwCF). Several studies have shown that AGs have a cumulative effect on ototoxicity. We aimed to investigate the relationship between AG exposure and ototoxicity by using 3 different methods in patients with CF.
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- Genetic variants in the CFTR gene cause cystic fibrosis (CF), and this study explores the genotypic and phenotypic diversity of CF in patients at a major CF center in Turkey.
- The analysis involved 481 individuals, revealing 136 different CFTR variants and identifying novel variants specific to the Turkish population, indicating unique genetic characteristics compared to averages in the US and Europe.
- The findings emphasize the importance of comprehensive genetic profiling in diverse populations to improve personalized treatment for CF, especially in light of new CFTR modulators.
Background: Cystic fibrosis (CF) patients have a limited life expectancy, but significant medical advances now highlight the need for successful transition programs from pediatric to adult care. The goal of this project was to introduce the transition program CF R.I.
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- Duchenne muscular dystrophy (DMD) is a common muscle disease that requires regular checks of respiratory muscle function, so this study focused on the relationship between various respiratory pressure measurements and lung function tests in DMD patients.
- The research included 44 DMD patients, with findings showing significant decreases in lung function when lying down, and notably lower respiratory pressure measurements in those with low body mass index (BMI).
- The study suggests that to properly evaluate respiratory strength, both standing and lying down lung function tests should be used together and stresses the importance of monitoring nutrition for maintaining respiratory health in these patients.
Article Synopsis
- - Cystic fibrosis (CF) is caused by mutations in the CFTR gene, with over 2000 identified variants, and new drugs called CFTR modulators are only effective for patients with specific variants, leading to disparities in access based on race and location.
- - A study at Marmara University reviewed 445 CF patients, finding that 31.2% were ineligible for CFTR modulators, identifying 60 different variants, most of which were missense or nonsense types, with c.1545_1546del being the most common in that region.
- - The research emphasizes the need for detailed genetic testing of CF patients who can't use current drugs, suggesting that new strategies must be developed to ensure all patients
Background: The aim of this study was to evaluate the prevalence of anxiety, depression, sleep, and associated factors in caregivers of children with spinal muscular atrophy (SMA).
Materials And Methods: Beck Depression Inventory (BDI), the State-Trait Anxiety Inventory-State (STAI-S), the State-Trait Anxiety Inventory-Trait (STAI-T), and Pittsburgh Sleep Quality Index (PSQI) were used to assess the anxiety, depression, and sleep quality of the caregivers of children with SMA. Higher scores indicated worse outcome for all three questionnaires.