Publications by authors named "Sewanou Hermann Honfo"
Article Synopsis
- The study examines the long-term outcomes of patients with univentricular heart and total cavopulmonary connection Fontan, focusing on those with hypoplastic left heart syndrome (HLHS) compared to other types.
- The research found that patients with HLHS experienced a significantly higher incidence of adverse cardiovascular events, including death and transplantation, with a hazard ratio indicating over six times the risk.
- The findings suggest that HLHS is a critical factor in determining poorer outcomes in patients with this heart condition.
Background: There is a paucity of data on long-term outcomes after Fontan palliation in patients with a dominant morphological univentricular right (uRV) vs left (uLV) ventricle.
Objectives: The purpose of this study was to compare the incidence of atrial arrhythmias, thromboembolic events, cardiac transplantation, and death following Fontan palliation in patients with uRV vs uLV.
Methods: The Alliance for Adult Research in Congenital Cardiology conducted a multicenter retrospective cohort study on patients with total cavopulmonary connection Fontan palliation across 12 centers in North America.
Article Synopsis
- The study explored the use of Bayesian latent class models (BLCMs) to estimate the presence of anti-SARS-CoV-2 antibodies in blood donor samples, without relying on a definitive testing standard.
- A total of 6,810 plasma samples from blood donors in Québec collected between May and July 2020 were tested with seven different serological assays, revealing a SARS-CoV-2 seroprevalence of 0.71%.
- The research highlighted the variability in sensitivity among the assays used and emphasized that BLCMs can provide rapid updates on disease prevalence and assist public health efforts, especially when a gold standard test is unavailable.
Physiological Dysregulation Proceeds and Predicts Health Outcomes Similarly in Chinese and Western Populations.
J Gerontol A Biol Sci Med Sci
January 2024
Background: A decade ago, we proposed an index of physiological dysregulation based on Mahalanobis distance (DM) that measures how far from the norm an individual biomarker profile is. While extensive validation has been performed, focus was mostly on Western populations with little comparison to developing countries, particularly at a physiological system level. The degree to which the approach would work in other sociocultural contexts and the similarity of dysregulation signatures across diverse populations are still open questions.
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