[The resistance rates of Mycobacterium tuberculosis strains to antituberculosis drugs: evaluation of two years' data in Aegean region, Turkey].

The aim of this study was to determine the primary, secondary and total resistance rates of Mycobacterium tuberculosis strains in the Aegean Region, Turkey, between November 1st 1999 and November 30th 2001. A total of 490 M. tuberculosis strains isolated from patients admitted to 27 different tuberculosis dispensaries, were evaluated.

Characterization of rpoB mutations in rifampin-resistant clinical isolates of Mycobacterium tuberculosis from Turkey by DNA sequencing and line probe assay.

Mutations in an 81-bp region of the rpoB gene associated with rifampin resistance were studied in 41 rifampin-resistant clinical strains of Mycobacterium tuberculosis isolated in Turkey. Fourteen different rpoB alleles, three of which had not been reported before, were found. A reverse hybridization-based line probe assay (the Inno-LiPA Rif.