Schiff Base-platinum and ruthenium complexes and anti-Alzheimer properties.

This study investigates the effects of Pt and Ru complexes containing a Schiff base with a diimine structure on Alzheimer's disease. The Schiff base (N1E,N2E)-N1,N2-bis(isoquinolin-4-ylmethylene)benzene-1,2-diamine (I) and the novel Pt(II) and Ru(II) complexes (Ia and Ib) were synthesized and characterized using FTIR, NMR (H, C), mass spectrometry, and elemental analyses. Their ability to inhibit amyloid beta (Aβ) aggregation was determined in vitro using the SH-SY5Y cell line.

3-[(Diphenylphosphinothioyl)oxy]-N-methylpropan-1-aminium diphenylphosphanylthioate.

The title salt, C16H21NOPS(+) · C12H10OPS, was synthesized from the reaction between 3-(methylamino)propan-1-ol and PPh2(S)Cl in the presence of Et3N. Its structure has been identified using spectroscopic methods and X-ray analysis. Single crystals were obtained from ethanol by slow evaporation.

Bis[bis-(diphenyl-thio-phosphin-yl)amido-κS,S']platinum(II).

In the title compound, [Pt(C(24)H(20)NP(2)S(2))(2)], the Pt atom is in a distorted square-planar environment and contains two six-membered carbon-free chelate rings, one in twist-boat and the other in a half-chair conformation. Two phenyl groups are disordered over two set of sites in ratios of 0.721 (13):0.