Islet auto transplantation following total pancreatectomy: a long-term assessment of graft function.

Unlabelled: Total pancreatectomy is considered the final resort in the treatment of chronic pancreatitis; however, here we show that simultaneous islet autotransplantation can abrogate the onset of diabetes.

Methods: : In Leicester, 46 patients have now undergone total pancreatectomy with immediate islet auto transplant, and they have received a median of 2246 islet equivalent (IEQ)/kg body weight (range, 405-20,385 IEQ/kg body weight).

Results: : Twelve patients have shown periods of insulin independence, for a median of 16.