Publications by authors named "Severina N"
Article Synopsis
- * The study examined gene mutations and chromosomal changes in 152 CLL patients in Russia, finding that certain subgroups of stereotyped antigenic receptors (SAR) had a higher frequency of these genetic lesions compared to the average.
- * Differences in mutation profiles among SAR subgroups were noted, highlighting the need for further research to understand CLL better and improve treatment strategies.
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of diseases, which accounts for 30% of all non-Hodgkin lymphomas. Current molecular studies have confirmed that there are several DLBCL subtypes characterized by different cellular origin, cytogenetic profile, molecular genetic disorders, and different pathogenesis. Impaired JAK-STAT signaling is a part of the pathogenesis of various cancers, including DLBCL.
View Article and Find Full Text PDFEvolutionarily conserved gene family important for fat storage.
Proc Natl Acad Sci U S A
January 2008
The ability to store fat in the form of cytoplasmic triglyceride droplets is conserved from Saccharomyces cerevisiae to humans. Although much is known regarding the composition and catabolism of lipid droplets, the molecular components necessary for the biogenesis of lipid droplets have remained obscure. Here we report the characterization of a conserved gene family important for lipid droplet formation named fat-inducing transcript (FIT).
View Article and Find Full Text PDF