Survey of Postoperative Pain in Photorefractive Keratectomy Using Topical versus Oral Nonsteroidal Anti-Inflammatory Drugs.

Purpose: To evaluate and compare postoperative pain following photorefractive keratectomy (PRK) in patients using a preventive regimen of oral versus topical nonsteroidal anti-inflammatory drugs (NSAIDs).

Patients And Methods: A prospective, randomized, longitudinal survey of postoperative PRK pain was performed on 157 subjects in a tertiary academic medical center setting. Patients were randomized to either topical ketorolac 0.

Outcomes of resident-performed laser-assisted vs traditional phacoemulsification.

Purpose: To compare the effectiveness of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification cataract surgery (CPS) by resident surgeons.

Setting: Parkland Memorial Health and Hospital System, Dallas, Texas, USA.

Design: Prospective randomized study.

High myopic photorefractive keratectomy outcomes with the Alcon Wavelight EX500 excimer laser.

Purpose: To present refractive outcomes from consecutive cases with the Alcon Wavelight EX500 excimer laser using photorefractive keratectomy (PRK) in patients with high myopia.

Methods: A retrospective chart review of consecutive cases of high myopic eyes (≥6.0 Diopters [D]) undergoing PRK with the Alcon Wavelight EX500 excimer laser (Alcon Laboratories, Fort Worth, TX, USA) was done.

Retinal MMP-12, MMP-13, TIMP-1, and TIMP-2 expression in murine experimental retinal detachment.

Purpose: Matrix metalloproteinases (MMPs) and their inhibitors play a role in the pathobiology of retinal detachment (RD) and proliferative vitreoretinopathy (PVR). Proliferative vitreoretinopathy is facilitated by chronic retinal detachment and involves excessive deposition of extracellular matrix (ECM) proteins. Matrix metalloproteinase-2 and -13 are important modulators of the ECM which have not been evaluated in RD.

A scoring system for the prognosis and treatment of malignant bowel obstruction.

Background: Malignant bowel obstruction is a common result of end-stage abdominal cancer that is a treatment dilemma for many physicians. Little has been reported predicting outcomes or determining the role of surgical intervention. We sought to review our experience with surgical and nonsurgical management of malignant bowel obstruction to identify predictors of 30-day mortality and of who would most likely benefit from surgical intervention.

An analysis of the use of multiple comparison corrections in ophthalmology research.

Purpose: The probability of type I error, or a false-positive result, increases as the number of statistical comparisons in a study increases. Statisticians have developed numerous corrections to account for the multiple comparison problem. This study discusses recent guidelines involving multiple comparison corrections, calculates the prevalence of corrections in ophthalmic research, and estimates the corresponding number of false-positive results reported at a recent international research meeting.