Idiopathic membranous nephropathy associated with polycystic kidney disease.

Membranous nephropathy (MN) and polycystic kidney disease are both relatively rare diseases in children. On rare exceptions, these two conditions have been associated in adults. We report here the first case of a pediatric patient with this association.

Risk factors for cyclosporin A nephrotoxicity in children with steroid-dependant nephrotic syndrome.

Background And Objectives: Cyclosporin A (CsA) is a well-established treatment for steroid-dependent nephrotic syndrome (SDNS) that may, however, cause chronic ischemic renal lesions. The objective of the study was to assess the prevalence of CsA nephrotoxicity (CsAN) in protocol biopsies of children with SDNS.

Design, Settings, Participants, & Measurements: From 1990 through 2008, we performed 71 renal biopsies in 53 patients with SDNS.

Residual renal function and nutrition in young patients on chronic hemodialysis.

Residual renal function (RRF) has been associated with a better nutritional status in adult patients on chronic dialysis, but there is as yet no data available for young patients on chronic hemodialysis (HD). We have retrospectively analyzed 3-day dietary reports and simultaneous urea kinetic monitoring data (n = 179) of 30 children, adolescents and young adults on chronic HD. The protein catabolic rate (PCR) was calculated and normalized by body weight (nPCR).