Publications by authors named "Severin Jeanneret"
Background: Hospitalized patients with COVID-19 suffered initially from high rates of venous thromboembolism (VTE), with possible associations between therapeutic anticoagulation and better clinical outcomes in observational studies.
Objective: To test whether therapeutic anticoagulation improves clinical outcomes in severe COVID-19.
Patients/methods: In this multicenter, open-label, randomized controlled trial, we recruited acutely ill medical COVID-19 patients with D-dimer >1000 ng/ml or critically ill COVID-19 patients in four Swiss hospitals, from April 2020 until June 2021, with a 30-day follow-up.
Article Synopsis
- - The study examined the prevalence of venous thromboembolism (VTE) in critically ill COVID-19 patients by conducting lower limb ultrasound screenings in an ICU setting.
- - Out of 25 enrolled patients, 32% were found to have VTE, with 24% presenting symptomatic deep vein thrombosis (DVT) and 20% having pulmonary embolism.
- - Conclusions suggest that early screening for DVT in the first week of ICU admission could improve patient care, as most VTE cases occurred prior to the scheduled screening.
In Rendu-Osler disease, haemorrhages due to gastrointestinal vascular malformations are common. Surgical and endoscopic treatments for haemorrhage due to gastrointestinal vascular malformations are compromised when lesions are diffuse, escape identification or are inaccessible to treatment. Hormonal treatment with oestrogen and progestagens is still controversial based on contradictory results from two randomised clinical trials.
View Article and Find Full Text PDFIntroduction: The main clinical manifestations of Whipple's disease are weight loss, arthropathy, diarrhea and abdominal pain. Cardiac involvement is frequently described. However, endocarditis is rare and is not usually the initial presentation of the disease.
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