Can 68Ga-PSMA PET/CT-derived prostate-specific membrane antigen expression parameters predict prostate-specific antigen response to enzalutamide treatment?

Objective: In patients with metastatic castration-resistant prostate cancer (mCRPCa), enzalutamide is administered when docetaxel treatment fails. The purpose of the study was to evaluate the relationship between prostate-specific antigen (PSA) response and metabolic parameters obtained from 68Ga-PSMA PET/CT before treatment in this patient group.

Methods: From February 2018 to May 2020, 34 patients with mCRPCa were enrolled in this study.

The relationship between pre-treatment F-FDG PET/CT metabolic data and treatment response in patients with cervix uteri cancer.

Objective: To determine the risk group of patients with locally advanced squamous cell carcinoma of the uterine cervix that will resist to treatment before concomitant chemoradiotherapy and who will develop metastasis via fluorine-18-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) metabolic data.

Subjects And Methods: Fifty two patients with carcinoma of the uterine cervix who were treated in our clinic between 2015-2018 were evaluated. The presence of human papilloma virus (HPV) from the first paraffin blocks diagnosed in all patients has been tested withreal time polymerase chain reaction (PCR).

The Predictive Value of Baseline Volumetric PET/CT Parameters on Treatment Response and Prognosis in Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy.

Purpose: To investigate the prognostic effects of baseline volumetric PET/CT parameters including the maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), and tumor lesion glycolysis (TLG) on treatment response and prognosis in locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (NACRT).

Methods: Between 2015 and 2018, 51 patients with LARC treated with NACRT followed by surgery were included in this retrospective study. Patients were divided into 2 groups by tumor regression grade (TRG) as follows: group I = TRG 1 (no detectable cancer cells) + TRG 2 (single cells and/or small groups of cancer cells) and group II = TRG3 (residual tumor outgrown by fibrosis) + TRG 4 (remarkable fibrosis outgrown by tumor cells) + TRG 5 (no fibrosis with extensive residual cancer).

Correlations of the Ga-PSMA PET/CT derived primary prostate tumor PSMA expression parameters and metastatic patterns in patients with Gleason Score >7 prostate cancer.

Objective: We aimed to investigate the correlations between the prostate specific membrane antigen (PSMA) expression parameters of the primary prostate tumor on gallium-68 (Ga)-PSMA positron emission tomography/computed tomography (PET/CT) with metastatic patterns in patients with Gleason Score (GS) >7 prostate cancer (PCa).

Materials And Methods: This study included 55 PCa patients who had Ga-PSMA PET/CT performed for staging. According to metastatic pattern, patients were divided into 3 groups as non-metastatic (N0M0), those with isolated pelvic lymph node metastasis (N1M0) and with distant metastasis (M1).

The predictive role of metabolic tumor volume on no response to neoadjuvant chemotherapy in patients with breast cancer.

Introduction: To evaluate the predictive significance of pretreatment metabolic tumor volume on pathologic response in patients who received neoadjuvant chemotherapy for breast cancer.

Methods: Seventy patients who received neoadjuvant chemotherapy between 2013 and 2017 years were enrolled in the study. Pathologic responses and 18-fluorodeoxyglucose positron emission tomography/computed tomography metabolic dates of patients were obtained from archive files.

Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter.

Ectopic thyroid tissue has been found from the tongue to the diaphragm. The most common ectopic thyroid tissue has been found in the tongue, submandibular region, cervical lymph nodes, larynx, trachea, oesophagus, mediastinum, diaphragm and heart respectively. "Forgotten goiter" is an extremely rare disease which is defined as a mediastinal thyroid mass found after total thyroidectomy.

Haematogenous muscular metastasis of non-small cell lung cancer in F-18 fluorodeoxyglucose positron emission tomography/computed tomography.

Aim Of The Study: F-18 FDG PET/CT is the most effective method for demonstrating extrapulmonary metastases of lung cancer. The aim of this study is to investigate the level of muscular metastasis of non-small-cell lung carcinoma (NSCLC) in F-18 FDG PET/CT and to demonstrate the characteristics of this special group of patients.

Material And Methods: A total of 1150 patients with the diagnosis of NSCLC, who were referred for F-18 FDG PET/CT, were included into the study.

Relationship between pretreatment levels of serum Cyfra 21.1, CEA and PET metabolic parameters in NSCLC.

Objective: No investigation has been conducted on the association between PET findings and serum Cyfra 21.1 and CEA levels in nonsmall cell lung cancers (NSCLC). The purpose of this study is to find out if the serum levels of Cyfra 21.

Abdominal lymph node metastasis in patients with non-small-cell lung cancer as shown by PET/CT.

Purpose: The aim of this study is to investigate the frequency and the spread of abdominal lymph node metastasis in patients with non-small-cell lung cancer (NSCLC) by (18)F-FDG PET/CT.

Patients And Methods: Retrospective evaluation of the (18)F-FDG PET/CT examinations of 1191 patients diagnosed with NSCLC was performed. The metastatic abdominal lymph nodes of the patients were classified as inside the routine imaging field (covering the field of chest CT including adrenal glands) and outside the field.

Gamma Probe Guided Minimally Invasive Parathyroidectomy without Quick Parathyroid Hormone Measurement in the Cases of Solitary Parathyroid Adenomas.

Objective: In this study, our aim was to study the efficiency of gamma probe guided minimally invasive parathyroidectomy (GP-MIP), conducted without the intra-operative quick parathyroid hormone (QPTH) measurement in the cases of solitary parathyroid adenomas (SPA) detected with USG and dual phase 99mTc-MIBI parathyroid scintigraphy (PS) in the preoperative period.

Material And Methods: This clinical study was performed in 31 SPA patients (27 female, 4 male; mean age 51±11years) between February 2006 and January 2009. All patients were operated within 30 days after the detection of the SPA with dual phase 99mTc-MIBI PS and USG.

Tc-99m radio-guided completion thyroidectomy for differentiated thyroid carcinoma.

Background: The purpose of this study is to investigate whether or not radio-guided surgery has any beneficial effects on completion thyroidectomy (CT) and the associated complication rates.

Patients And Methods: Twenty-seven patients were scheduled for CT, for thyroid carcinoma, from December 2004 to June 2005, and were included in the study. All the patients had had initial thyroid surgery in other centers and been referred to our clinic for CT.

Subcutaneous metastases of colorectal cancer detected with PET/CT.

Cutaneous and subcutaneous metastases of colorectal cancer is rare. The authors present a case of a 63-year-old man with colorectal carcinoma, who underwent preoperative staging with positron emission tomography/computed tomography (PET/CT). PET/CT demonstrated intensely increased uptake in the subcutaneous nodular lesion in the anterior surface of the right thigh.

Gamma probe (99m)Tc-pertechnetate assisted completion thyroidectomy vs conventional thyroidectomy in differentiated thyroid carcinoma.

Patients undergoing partial thyroidectomy for benign diseases may need re-operation if differentiated thyroid carcinoma (DTC) is detected on histopathology. The aim of this study was to determine if using gamma probe during the above surgery in a procedure called: gamma probe completion thyroidectomy (GPCT) could support the diagnosis of DTC tissue and offer an advantage in the surgical treatment of DTC patients. We have studied 100 patients who after bilateral subtotal thyroidectomy for benign disease in several hospitals, were found to have DTC histopathologically and referred to our clinic for subsequent re-operation.

Chronic bronchitis mimicking metastases from thyroid medullary carcinoma demonstrated by indium-111 pentetreotide scintigraphy.

We present a case of medullary thyroid carcinoma (MTC) with pulmonary symptoms, elevated calcitonin and CEA levels. Both [111In]pentetreotide (Octreoscan) scintigraphy and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) scan revealed mild increased uptake of radionuclides in the upper lobe of the right lung compatible with metastases. Histopathological analysis showed it to be chronic bronchitis.