Publications by authors named "Seungyeon Choi"

Unlabelled: Archaea catalyzing the first step of nitrification in the rhizosphere possibly have an influence on plant growth and development. In this study, we found a distinct archaeal community, dominated by ammonia-oxidizing archaea (AOA), associated with the root system of pepper ( L.) and ginseng plants ( C.

View Article and Find Full Text PDF
Article Synopsis
  • Designing drugs that can effectively bind to target proteins is crucial for treating diseases, and advancements in geometric deep learning have improved how ligands are generated in 3D.
  • Many existing methods mainly focus on the geometric modeling of ligands, ignoring the fundamental physicochemical principles that drive protein-ligand interactions.
  • The proposed model, PIDiff, incorporates these principles to optimize ligand binding by minimizing binding free energy, showing superior performance in assessments compared to traditional methods and existing models.
View Article and Find Full Text PDF
Article Synopsis
  • - The gut microbiota composition affects the immune system and is linked to diseases like allergies and inflammation; however, more research is needed on microbial therapies.
  • - The study compared the bacterial consortium MPRO (HY7712, HY8002, HY2782) with its individual strains, finding that MPRO was more effective in treating atopic dermatitis and inflammatory colitis.
  • - Administration of MPRO reduced inflammation and changed the gut microbiome, resulting in increased immune cells that help suppress inflammation, suggesting that combined bacterial treatments may be more beneficial than single strains.
View Article and Find Full Text PDF

The discovery of drugs to selectively remove disease-related cells is challenging in computer-aided drug design. Many studies have proposed multi-objective molecular generation methods and demonstrated their superiority using the public benchmark dataset for kinase inhibitor generation tasks. However, the dataset does not contain many molecules that violate Lipinski's rule of five.

View Article and Find Full Text PDF

Purpose: This work describes the hardware and software developments of a prototype chest digital tomosynthesis (CDT) R/F system. The purpose of this study was to validate the developed system for its possible clinical application on low-dose chest tomosynthesis imaging.

Methods: The prototype CDT R/F system was operated by carefully controlling the electromechanical subsystems through a synchronized interface.

View Article and Find Full Text PDF

Dose reduction techniques have been studied in medical imaging. We propose shutter scan acquisition for region of interest (ROI) imaging to reduce the patient exposure dose received from a digital tomosynthesis system. A prototype chest digital tomosynthesis (CDT) system (LISTEM, Wonju, Korea) and the LUNGMAN phantom (Kyoto Kagaku, Japan) with lung nodules 8, 10, and 12 mm in size were used for this study.

View Article and Find Full Text PDF

Lithium (Li) is a core element of Li-ion batteries (LIBs). Recent developments in mobile electronics such as smartphones and tablet PCs as well as advent of large-scale LIB applications including electrical vehicles and grid-level energy storage systems have led to an increase in demand for LIBs, giving rise to a concern on the availability and market price of Li resources. However, the current Lime-Soda process that is responsible for greater than 80% of worldwide Li resource supply is applicable only in certain regions on earth where the Li concentrations are sufficiently high (salt lakes or salt pans).

View Article and Find Full Text PDF

Objective: To investigate associations between angiotensin-converting enzyme (ACE) polymorphisms and muscle fatigability in 65-year-old Koreans.

Method: The study participants were 49 Koreans aged 65 years. ACE insertion/deletion (I/D) polymorphisms were determined by polymerase chain reaction and serum ACE activity, by spectrophotometry.

View Article and Find Full Text PDF

A 46-year-old woman presented with whole abdominal discomfort, and imaging revealed a 3-cm-sized ill-defined ovarian mass with extensive peritoneal carcinomatosis. Histologic examination showed malignant fibrous histiocytoma of ovary with predominant myxoid stroma. Microscopic examination showed a highly cellular neoplasm composed of fibroblast-like cells with a predominant myxoid stroma and high pleomorphism and mitotic activity.

View Article and Find Full Text PDF