Publications by authors named "Seungmin Ryou"
Article Synopsis
- - Researchers have developed advanced tools, like DdCBEs and TALEDs, to specifically edit mitochondrial DNA, which is important for studying and treating genetic disorders.
- - While A-to-G-editing TALEDs caused a lot of unwanted changes in RNA, newly engineered TALED variants drastically reduced these off-target effects by more than 99%.
- - The improved TALED variants were safe for use in mice, leading to models with specific mitochondrial mutations that display symptoms related to Leigh syndrome without causing negative side effects like developmental issues.
