MotGen: a closed-loop bacterial motility control framework using generative adversarial networks.

Motivation: Many organisms' survival and behavior hinge on their responses to environmental signals. While research on bacteria-directed therapeutic agents has increased, systematic exploration of real-time modulation of bacterial motility remains limited. Current studies often focus on permanent motility changes through genetic alterations, restricting the ability to modulate bacterial motility dynamically on a large scale.

Immune Activation Modulation via Magnetically Localized Bacteria Based Micro/Bio Robot (BBMBR).

Understanding tumor's microenvironment is one of the key factors in the cancer therapy. Especially, from the perspective of immunotherapy, immune desert or cold tumor is referred as significantly downregulated T cell in-filtration due to lack of immune surveillance in the tumor microenvironment. There are many studies are dedicated to convert cold tumor to hot tumor for enhancing the efficacy of immunotherapy.

Standard for the Quantification of a Sterilization Effect Using an Artificial Intelligence Disinfection Robot.

Recent outbreaks and the worldwide spread of COVID-19 have challenged mankind with unprecedented difficulties. The introduction of autonomous disinfection robots appears to be indispensable as consistent sterilization is in desperate demand under limited manpower. In this study, we developed an autonomous navigation robot capable of recognizing objects and locations with a high probability of contamination and capable of providing quantified sterilization effects.

Erratum: Multicolor fluorescence imaging using a single RGB-IR CMOS sensor for cancer detection with smURFP-labeled probiotics: publisher's note.

[This corrects the article on p. 2951 in vol. 11, PMID: 32637234.

Artificial Neural Network enabling Clinically Meaningful Biological Image Data Generation.

Biological experiments for developing efficient cancer therapeutics require significant resources of time and costs particularly in acquiring biological image data. Thanks to recent advances in AI technologies, there have been active researches in generating realistic images by adapting artificial neural networks. Along the same lines, this paper proposes a learning-based method to generate images inheriting biological characteristics.

Multicolor fluorescence imaging using a single RGB-IR CMOS sensor for cancer detection with smURFP-labeled probiotics.

A multicolor fluorescence imaging device was recently developed for image-guided surgery. However, conventional systems are typically bulky and function with two cameras. To overcome these issues, we developed an economical home-built fluorescence imaging device based on a single RGB-IR sensor that can acquire both color and fluorescence images simultaneously.

Nanoscale Bacteria-Enabled Autonomous Drug Delivery System (NanoBEADS) Enhances Intratumoral Transport of Nanomedicine.

Cancer drug delivery remains a formidable challenge due to systemic toxicity and inadequate extravascular transport of nanotherapeutics to cells distal from blood vessels. It is hypothesized that, in absence of an external driving force, the serovar Typhimurium could be exploited for autonomous targeted delivery of nanotherapeutics to currently unreachable sites. To test the hypothesis, a nanoscale bacteria-enabled autonomous drug delivery system (NanoBEADS) is developed in which the functional capabilities of the tumor-targeting .

Design And Experiment Of A Passive Sit-To-Stand And Walking (STSW) Assistance Device For The Elderly.

Most elderly people complain about the discomfort of movements such as a sit-to-stand (STS) motion through losing their muscular strength of lower extremity over aging. This paper presents a novel passive sit-to-stand and walking (STSW) assistance device to aid in physical support for indoor daily life of the elderly. The STSW assistance device is actuated by a pneumatic cylinder and a gas spring.

Optimizing the restored chemotactic behavior of anticancer agent Salmonella enterica serovar Typhimurium VNP20009.

Bacteria, including strains of Salmonella, have been researched and applied as therapeutic cancer agents for centuries. Salmonella are particularly of interest due to their facultative anaerobic nature, facilitating colonization of differentially oxygenated tumor regions. Additionally, Salmonella can be manipulated with relative ease, resulting in the ability to attenuate the pathogen or engineer vectors for drug delivery.

Bacterial chemotaxis-enabled autonomous sorting of nanoparticles of comparable sizes.

High throughput sorting of micro/nanoparticles of similar sizes is of significant interest in many biological and chemical applications. In this work, we report a simple and cost-effective sorting technique for separation of similarly-sized particles of dissimilar surface properties within a diffusion-based microfluidic platform using chemotaxis in Escherichia coli bacteria. Differences in surface chemistry of two groups of similarly-sized nanoparticles in a mixture were exploited to selectively assemble one particle group onto motile E.